🟢 86/100

This product is generally safe

  • Folate: 333mg is 333.0× the Tolerable Upper Intake Level (1.0mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 80% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 333mg is 333.0× the Tolerable Upper Intake Level (1.0mg)
ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

0.5233 Gram(s) Serving Size
60 Servings
Other Combinations Product Type
80% Evidence Coverage

Supplement Facts — Evidence Check

1 mg (83% DV)
✅ Within RDA (0.8× RDA of 1.2 mg) 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 1mg
1.5 mg (115% DV)
✅ 1.2× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 1.5mg
10 mg (63% DV)
✅ Within RDA (0.7× RDA of 14 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 10mg UL 35mg
1.5 mg (88% DV)
✅ 1.2× RDA — within safe limits 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 1.5mg UL 100mg
333 mcg DFE (83% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 333.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 333mg UL 1.0mg
7.5 mcg (313% DV)
📊 3.1× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.0075mg
80 mcg (267% DV)
✅ 2.7× RDA — within safe limits 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.08mg
5 mg (100% DV)
✅ Within RDA (1.0× RDA of 5 mg) 📚 1 studies — no high-quality reviews
RDA 5mg This product: 5mg
3.5 mg (1% DV)
📊 Market median: 125.0mg (294 products) 📚 36 studies (Tier A: 1, B: 7)
RDA 550mg This product: 3.5mg UL 3500mg
Proprietary Blend
918 mg

Other Ingredients

natural Raspberry flavor Citric Acid Luo Han fruit juice concentrate Malic Acid Stevia leaf extract

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Recommendation: Add 1-3 level scoops in 2 oz. water twice daily. Mix well and drink immediately. 1/4 teaspoon = Approx. 1 level scoop. Scoop included.

⚠️ Warnings & Precautions

Notice: Pregnant or lactating women should consult their health care professional prior to taking this supplement.

This bottle was sealed for your protection. Do not use if inner seal is missing or damaged.

Additional Information

010018430917 Nervous and circulatory system support Guaranteed pure

Nature's Sunshine uses natural source materials that are subject to color variation. Since 1972 Quality, service, integrity Supports normal brain stimulation levels Supports blood circulation and neurotransmitters in the brain

Store in a cool, dry place tightly covered.

Product of U.S.A.

Product Details

UPC / SKU 0 99904 01843 3
DSLD Entry Date 2019-10-23
Product Type Other Combinations
Form Powder
DSLD ID 207554
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
View all evidence for Thiamine →

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