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Cortisol (Serum)
Primary stress hormone; follows diurnal rhythm
Also known as: AM Cortisol
Reference Ranges
Clinical Reference
6.2 – 19.4 ug/dL
Optimal Range
10.0 – 18.0 ug/dL
Critical Range
< 3.0
/
> 50.0
ug/dL
Morning sample (7-10am)
Related Conditions
Cushings Syndrome
High
Chronic Stress
High
Addisons Disease
Low
Adrenal Insufficiency
Low
Food & Lifestyle Recommendations
🍎 Food
Avoid late-night caffeine; stabilize blood sugar with balanced meals
Caffeine and hypoglycemia spike cortisol
🍎 Food
Eat regular meals with adequate salt and protein; support adrenal function
Stabilizes fuel for adrenal output
🏃 Exercise
Moderate exercise daily; avoid excessive endurance training (raises cortisol chronically)
Exercise dose matters
🏃 Exercise
Gentle exercise (walking, yoga); avoid overtraining which worsens adrenal output
Low cortisol requires restorative movement
😴 Sleep
Consistent sleep schedule 10pm-6am; cortisol rhythm needs anchored sleep times
Circadian cortisol regulation
🧘 Stress
Daily meditation/breathwork (10-20 min); reduces cortisol by 15-25% in RCTs
Well-documented stress-reduction effects
Evidence-Backed Supplements
When High
-
Multiple RCTs show cortisol reduction in stressed adults
KSM-66 or Sensoril 300–600 mg/day With meals -
Blunts exercise- and stress-induced cortisol spikes
Phosphatidylserine 300–600 mg/day Any -
Adaptogen; modulates HPA axis
Rhodiola rosea 3% rosavins 200–400 mg/day Morning -
Reduces stress-induced cortisol
L-Theanine 200 mg 1–2x/day Any
When Low
-
Inhibits cortisol breakdown; use with caution, raises BP
Glycyrrhizin 150–300 mg/day With meal -
Adrenal glands concentrate vitamin C; supports cortisol synthesis
Vitamin C 1000 mg/day Any
Questions to Ask Your Doctor
- Should we do a 24-hr urine cortisol or dexamethasone suppression test? Rules out Cushing's
- Could this be stress-related or indicate an underlying disorder? Distinguish functional from pathologic
- Should we test ACTH and do a stimulation test for Addison's? Essential adrenal workup
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