Sedaplex

product on market Capsule Integrative Therapeutics 🟢 Safety: 100/100
Brand: Integrative Therapeutics
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 55% of ingredients have research evidence
A Label Compliance Grade

Product Label

Label for Sedaplex
📄 Open Full PDF View on NIH DSLD →
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Label Data

1 Capsule(s) Serving Size
30 Servings
Other Combinations Product Type
55% Evidence Coverage

Supplement Facts — Evidence Check

Total Carbohydrates
1 Gram(s) (1% DV)
25 mg (125% DV)
✅ 1.8× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 25mg UL 35mg
15 mg (750% DV)
📊 11.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 15mg UL 100mg
Calcium
25 mg (3% DV)
25 mg (6% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 25mg
200 mg
📊 Market median: 300.0mg (214 products) 📚 23 studies (Tier A: 0, B: 6)
This product: 200mg
Hops (Humulus lupulus) strobile extract
150 mg
Jujube seed extract
150 mg
125 mg
📊 Market median: 250.0mg (60 products) 📚 7 studies (Tier A: 0, B: 1)
This product: 125mg
Skullcap (Scutellaria lateriflora) aerial parts extract
125 mg
100 mg
📊 Market median: 200.0mg (358 products) 📚 9 studies (Tier A: 0, B: 2)
This product: 100mg

Other Ingredients

Hydroxypropyl Methylcellulose Cellulose Calcium Laurate

Label Claims — Verification

❓ All Other
❓ Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

Recommendations: For daytime use, take 1 to 2 capsules daily or for nighttime use, take 1 to 2 capsules one-half hour before bedtime, or as recommended by your healthcare professional.

⚠️ Warnings & Precautions

Warning: Do not use this product if pregnant or nursing.

Do not use alcohol while using this product as it has sedative properties. Do not operate heavy equipment/machinery or drive while using this product.

If taking prescription drugs or tranquilizers, consult your healthcare professional prior to use.

🧪 Formulation Notes

Contains no sugar, salt, yeast, wheat, gluten, soy, dairy products, artificial colors, flavors, preservatives or ingredients of animal origin.

Additional Information

LZ246004.C01 B010134C

Restful sleep support

Product Details

UPC / SKU 8 71791 00293 7
DSLD Entry Date 2017-09-21
Product Type Other Combinations
Form Capsule
Brand Integrative Therapeutics
DSLD ID 78335
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
PubMed DOI Cochrane
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
PubMed DOI Cochrane
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
PubMed DOI
View all evidence for Niacin →

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