🟢 97/100

This product looks safe

  • Folate: 1600mg is 1600.0× the Tolerable Upper Intake Level (1.0mg)
  • 55% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 1600mg is 1600.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Veg Capsule(s) Serving Size
30 Servings
Other Combinations Product Type
55% Evidence Coverage

Supplement Facts — Evidence Check

25 mg (1471% DV)
📊 19.2× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 25mg UL 100mg
1600 mcg DFE (400% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1600.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 1600mg UL 1.0mg
50 mcg (2083% DV)
📊 20.8× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.05mg
15 mg (136% DV)
✅ 1.4× RDA — within safe limits 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 15mg UL 40mg
PepZin GI
75 mg
L-Carnosine
57 mg
6 mg
📊 Market median: 3.0mg (984 products) 📚 236 studies (Tier A: 2, B: 109)
This product: 6mg UL 10mg
200 mg
📊 Market median: 500.0mg (70 products)
Median 500.0mg This product: 200mg
100 mg
📊 Market median: 500.0mg (193 products) 📚 7 studies — no high-quality reviews
This product: 100mg
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 100mg
100 mg
📊 Market median: 500.0mg (180 products) 📚 5 studies (Tier A: 0, B: 1)
This product: 100mg

Other Ingredients

Cellulose powder Cellulose Silica Magnesium Stearate

Label Claims — Verification

All Other
Structure/Function
All Other (98% of products) Structure/Function (89% of products) Nutrient (43% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested Usage: Take 1-2 capsules 30 to 60 minutes before bedtime, or take as directed by your healthcare practitioner.

~ Use with GI Guard AM

⚠️ Warnings & Precautions

Cautions/Interactions: Do not drive or use machinery for 4 to 5 hours after taking melatonin. Theoretically, concomitant use of melatonin with alcohol, benzodiazepines, or other sedative drugs might cause additive sedation.

Melatonin may interact with anti-coagulant/anti-platelet medications, antidepressants, anti-hypertensives, anti-diabetes drugs, anti-neoplastic agents and other drugs. If you are taking any prescription medications or if you have glaucoma, consult your healthcare practitioner before using this product.

Do not eat freshness packet. Keep in bottle.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

🧪 Formulation Notes

How It Works: GI Guard PM is a nutritional formula with PepZin GI, melatonin, amino acids, and B vitamins designed to help maintain the strength and integrity of the gastrointestinal mucosal barrier.* GI Guard PM features PepZin GI, which has been shown in clinical studies to promote a healthy stomach lining and to support proper gut repair processes.*

Vegetarian/Vegan

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Additional Information

Melatonin, a potent free radical scavenger, is known to exist at high levels in the gut, where it exerts its protective effects against oxidative stress throughout the gastrointestinal tract.* Melatonin also helps support healthy gastric pH levels, normal pepsin production in the stomach, and helps to regulate proper intestinal motility.* B Vitamins and Amino Acids, such as Tryptophan are necessary for Melatonin synthesis.*

CODE P2997 V6

~ Supports nighttime gastric health and comfort

Product Details

UPC / SKU 7 07359 12997 9
DSLD Entry Date 2017-05-24
Product Type Other Combinations
Form Capsule
DSLD ID 73223
Data Updated 2026-04-11

Research Evidence

153 Research Sources
55 Avg Quality Score
71 Systematic Review
51 Meta Analysis
19 Rct
6 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022
View all evidence for Vitamin B6 →

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