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GI Guard PM

product on market Capsule Protocol For Life Balance Safety: 97/100
97/100

This product looks safe

  • Folate: 1600mg is 1600.0× the Tolerable Upper Intake Level (1.0mg)
  • 55% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

This formula combines B vitamins and zinc to support metabolic function and cellular health. Research provides moderate evidence that PepZin GI may assist in managing gastric mucosal integrity. The overall ingredient profile is supported by established nutritional data, though specific clinical evidence for this exact blend is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1600mg is 1600.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for GI Guard PM
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Veg Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
55%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

25 mg (1471% DV)
19.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
1600 mcg DFE (400% DV)
Exceeds UL by 1600.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
50 mcg (2083% DV)
20.8× RDA — above typical dose 139 studies (A:1, B:44)
15 mg (136% DV)
1.4× RDA — within safe limits 263 studies (A:6, B:134)
PepZin GI
75 mg
L-Carnosine
57 mg
6 mg
Market median: 3.0mg (984 products) 240 studies (A:2, B:109)
200 mg
Market median: 500.0mg (70 products)
100 mg
Market median: 500.0mg (193 products) 7 studies — no high-quality reviews
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
100 mg
Market median: 500.0mg (180 products) 5 studies (A:0, B:1)

Other Ingredients

Cellulose powder Cellulose Silica Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Usage: Take 1-2 capsules 30 to 60 minutes before bedtime, or take as directed by your healthcare practitioner.

~ Use with GI Guard AM

Warnings & Precautions

Cautions/Interactions: Do not drive or use machinery for 4 to 5 hours after taking melatonin. Theoretically, concomitant use of melatonin with alcohol, benzodiazepines, or other sedative drugs might cause additive sedation.

Melatonin may interact with anti-coagulant/anti-platelet medications, antidepressants, anti-hypertensives, anti-diabetes drugs, anti-neoplastic agents and other drugs. If you are taking any prescription medications or if you have glaucoma, consult your healthcare practitioner before using this product.

Do not eat freshness packet. Keep in bottle.

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation Notes

How It Works: GI Guard PM is a nutritional formula with PepZin GI, melatonin, amino acids, and B vitamins designed to help maintain the strength and integrity of the gastrointestinal mucosal barrier.* GI Guard PM features PepZin GI, which has been shown in clinical studies to promote a healthy stomach lining and to support proper gut repair processes.*

Vegetarian/Vegan

Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish or tree nut ingredients.

Additional Information

Melatonin, a potent free radical scavenger, is known to exist at high levels in the gut, where it exerts its protective effects against oxidative stress throughout the gastrointestinal tract.* Melatonin also helps support healthy gastric pH levels, normal pepsin production in the stomach, and helps to regulate proper intestinal motility.* B Vitamins and Amino Acids, such as Tryptophan are necessary for Melatonin synthesis.*

CODE P2997 V6

~ Supports nighttime gastric health and comfort

Metadata

Product Details

UPC / SKU7 07359 12997 9
DSLD Entry Date2017-05-24
Product TypeOther Combinations
FormCapsule
DSLD ID73223
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.