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SAMe 200 mg

product on market Tablet or Pill Protocol For Life Balance Safety: 90/100
90/100

This product looks safe

  • Folate: 800mg is 800.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

SAMe is supported by moderate evidence for mood support, while B6, folate, and B12 are essential cofactors for neurotransmitter synthesis. These ingredients collectively support methylation processes and neurological function. Research for this specific combination is limited, though individual components are well-studied.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 800mg is 800.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for SAMe 200 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
30
Servings
Other Combinations
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

4 mg (235% DV)
3.1× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
800 mcg DFE (200% DV)
Exceeds UL by 800.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
100 mcg (4167% DV)
41.7× RDA — above typical dose 139 studies (A:1, B:44)
400 mg
Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Cellulose Croscarmellose Sodium Magnesium Stearate Silica Stearic Acid Ascorbic Acid Citric Acid Enteric Coating
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Usage: Take 1-2 tablets 1 to 4 times daily, or as directed by your healthcare practitioner.

Warnings & Precautions

Cautions/Interactions: Theoretically, SAMe could increase the effects and adverse effects of products that increase serotonin levels, including 5-hydroxytryptophan (5-HTP), Hawaiian baby woodrose, L-tryptophan, and St. John's wort.

In addition, SAMe may interact with MAO inhibitors, L-Dopa, antidepressants and other serotonergic drugs. Consult healthcare practitioner if pregnant/nursing, taking medication, or have a medical condition, especially bipolar or anxiety disorders.

Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Do not eat freshness packets. Keep in bottle.

Formulation Notes

Vegetarian/Vegan

Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients.

Additional Information

Refrigeration recommended after opening.

How It Works: SAMe (S-adenosylmethionine), a compound native to the body, is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health.* Numerous studies have indicated that SAMe can help to alleviate transient normal aches and pains resulting from overexertion or stress.* In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in the maintenance of a positive mood.*

CODE P0138B V8

~ Supports nervous system and joint health* ~ Enteric coated

Metadata

Product Details

UPC / SKU7 07359 10138 8
DSLD Entry Date2017-04-25
Product TypeOther Combinations
FormTablet or Pill
BrandProtocol For Life Balance
DSLD ID72862
Data Updated2026-04-11
Research

Research Evidence

12
Research Sources
58
Avg Quality
8
Meta Analysis
3
Systematic Review
1
Rct
B S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B S-adenosyl methionine (SAMe) for depression in adults
Meta Analysis The Cochrane database of systematic reviews 2016 PubMed
B Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease
Meta Analysis Annals of the rheumatic diseases 2024 PubMed DOI
B SAMe-TT2R2 Score to Predict Time in Therapeutic Range of Vitamin K Antagonists in Asian and Non-Asian patients: A Systematic Review and Meta-analysis
Meta Analysis American journal of cardiovascular drugs : drugs, devices, and other interventions 2024 PubMed DOI
B S-Adenosylmethionine (SAMe) as an adjuvant therapy for patients with depression: An updated systematic review and meta-analysis
Meta Analysis General hospital psychiatry 2024 PubMed DOI
B S-adenosyl-L-methionine for alcoholic liver diseases
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B WITHDRAWN: S-adenosyl-L-methionine for alcoholic liver diseases
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
C S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis
Meta Analysis PloS one 2015 PubMed DOI
C S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review
Systematic Review Nutrients 2024 PubMed DOI
C SAMe-TT2R2 to Predict Clinical Outcomes and Time in Therapeutic Range in Patients on Vitamin K Antagonists: A Systematic Review and Meta-Analysis
Meta Analysis The Annals of pharmacotherapy 2024 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.