SAMe 200 mg
This product looks safe
- Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)
- 100% of ingredients have research evidence
What the Evidence Says
AI-generated · Qwen 3.6 · grounded in 1 source · methodologySAMe is supported by moderate evidence for mood support and joint health. The accompanying B vitamins, including B6, B12, and folate, serve as essential cofactors in neurotransmitter synthesis. Overall, clinical evidence for this specific combination is limited due to low coverage.
AI-generated summary based on research evidence. Not medical advice.
Safety Alerts
Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)
Product Label
Label Data
Supplement Facts — Evidence Check
Other Ingredients
Label Claims — Verification
Product Information
Directions for Use
Suggested Usage: Take 1 tablet 2 to 4 times daily, preferably on an empty stomach.
Warnings & Precautions
Caution: For adults only.
Individuals with bipolar depression, anxiety disorders or taking antidepressant medications should not take SAMe unless under professional medical supervision. Consult physician if pregnant/nursing, taking medication, or have a medical condition.
Keep out of reach of children.
Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.
Do not eat freshness packets. Keep in bottle.
Formulation Notes
With B-vitamin cofactors
Vegetarian/Vegan
Not manufactured with wheat, gluten, soy, milk, egg, fish or shellfish ingredients.
Additional Information
Refrigeration recommended after opening.
SAMe (S-adenosylmethionine), a compound native to the body, is a component of many biochemical reactions, including those that affect brain biochemistry and joint health.* SAMe is critical for the synthesis of neurotransmitters, is important for energy production in the brain, contributes to the maintenance of healthy cell membrane function, and influences cartilage metabolism.*
CODE 0138B V7
Nervous system support* Supports cartilage production*
Enteric coated
Amino Acids
Family owned since 1968.
GMP Quality Assured
Product Details
Research Evidence
Similar Products
This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.