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Vitamin B12-500

product on market Capsule ProCaps Laboratories Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 73% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

The formulation contains a blend of B-complex vitamins and Vitamin C, which are supported by strong evidence for maintaining energy metabolism and immune function. These ingredients play essential roles in cellular health and neurological support. However, the overall evidence coverage for this specific product profile remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Vitamin B12-500
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
360
Servings
Multi-Vitamin and Mineral (MVM)
Product Type
73%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin C
90 mg (150% DV)
5 mg (333% DV)
4.2× RDA — above typical dose 76 studies (A:0, B:33)
5 mg (294% DV)
3.8× RDA — above typical dose 13 studies (A:0, B:1)
5 mg (25% DV)
Within RDA (0.4× RDA) 196 studies (A:5, B:63)
5 mg (250% DV)
3.8× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
100 mcg (25% DV)
Within RDA (0.2× RDA) 226 studies (A:10, B:105)
500 mcg (8333% DV)
208.3× RDA — above typical dose 139 studies (A:1, B:44)
100 mcg (33% DV)
3.3× RDA — above typical dose 27 studies (A:0, B:11)
5 mg (50% DV)
Within RDA (1.0× RDA) 2 studies — no high-quality reviews
Calcium
100 mg (10% DV)
40 mg (10% DV)
Within RDA (0.1× RDA) 316 studies (A:8, B:159)

Other Ingredients

Gelatin
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

SUGGESTED USE Consume one or more capsules daily or as recommended by a health care professional. For best results take this product with food, preferably a complete meal. This product is most effective when used in conjunction with one of Andrew Lessman’s Life Rx(TM) multi-vitamin-mineral formulas. For answers to questions about the use of this product call 800.800.1200.

Formulation Notes

NO ADDITIVES.

500 mcg Vitamin B12 High Potency B-Complex

Additional Information

602371 05.26.10 PC

All-Solar Manufacturing

ProCaps(R)LABORATORIES

Andrew Lessman’s VITAMIN B12-500 delivers 500 mcg of natural Vitamin B12, which is generally viewed as the most important of all the B-Complex vitamins to supplement. This importance stems from B12’s long list of critical functions and the fact that it is by far the most difficult of all vitamins to absorb. Vitamin B12 is essential for all energy production given its critical role in the creation of hemoglobin without which oxygen is not transported and no energy created. Vitamin B12’s role in energy production does not end there, since we also cannot metabolize carbohydrates or burn fat without Vitamin B12. Perhaps even more important is B12’s vital role in the synthesis of our genetic material and its requirement for normal cell growth and development. Vitamin B12 also supports heart health due to its ability to help metabolize homocysteine, and B12 is also essential to support healthy immune and nervous system function. Like all the B-Complex vitamins, B12 is easily depleted by stress, but its enormous molecular size makes it by far the most difficult of all vitamins to absorb. It is also well-established that stress, aging and digestive issues only further reduce Vitamin B12’s already poor absorption. Equally well established are the failings of typical B12 supplements whose contents are easily destroyed by stomach acid. Our unique Vitamin B12 is protected from stomach acidity and its B12 is released in the small intestine where it can be absorbed. Given all the critical functions of Vitamin B12, along with its extremely poor absorption from food and ordinary supplements, we should all carefully consider a plan to intelligently supplement. Best of all, our Vitamin B12-500 is a pleasure to use, since it comes in a small, soft, easy-to-swallow capsule and is designed to be gentle even to the most sensitive stomachs.

PROTECTED FOR OPTIMUM ABSORPTION

UNSURPASSED. Purity. Quality. Integrity. Effectiveness. Andrew Lessman Founder of ProCaps Labs

Metadata

Product Details

DSLD Entry Date2012-01-25
Product TypeMulti-Vitamin and Mineral (MVM)
FormCapsule
DSLD ID4701
Data Updated2026-04-11
Research

Research Evidence

237
Research Sources
53
Avg Quality
83
Meta Analysis
74
Systematic Review
45
Rct
29
Clinical Trial
2
Guideline
2
Regulatory Source
1
Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021 PubMed DOI
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024 PubMed DOI
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020 PubMed DOI
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024 PubMed DOI
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024 PubMed DOI
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024 PubMed DOI
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.