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Positive Outlook

product on market Capsule Higher Nature Safety: 97/100
97/100

This product looks safe

  • Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
  • 64% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains a complex of B vitamins, including thiamine, niacin, and B12, which are supported by strong evidence for their role in energy metabolism and neurological function. Research indicates these nutrients are essential for maintaining cognitive health and supporting the nervous system. The ingredient profile is associated with a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Positive Outlook
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
Other Combinations
Product Type
64%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

25 mg (2273% DV)
20.8× RDA — above typical dose 76 studies (A:0, B:33)
40 mg NE (250% DV)
Exceeds UL by 1.1× (UL: 35 mg) 196 studies (A:5, B:63)
20 mg (1429% DV)
15.4× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
100 mcg (50% DV)
Within RDA (0.2× RDA) 226 studies (A:10, B:105)
10 mcg (400% DV)
4.2× RDA — above typical dose 139 studies (A:1, B:44)
90 mg (1500% DV)
18.0× RDA — above typical dose 2 studies — no high-quality reviews
430 mg
Market median: 500.0mg (223 products) 24 studies (A:0, B:1)
500 mg
Market median: 420.0mg (227 products)
90 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
Tri-Methyl Glycine
220 mg
Melissa officinalis
50 mg

Other Ingredients

L-Glutamine L-Tyrosine Betaine Monohydrate Hydroxypropyl Methylcellulose Calcium D-Pantothenate L-5-Hydroxytryptophan Melissa officinalis Niacin Thiamine Hydrochloride Pyridoxine Hydrochloride Magnesium Stearate Silicon Dioxide Folic Acid Methylcobalamin
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

DIRECTIONS: Take 2 capsules once or twice a day (children over 6 years, 1 a day), preferably on an empty stomach or with a non-protein snack, or as your health professional advises. Do not exceed recommended daily intake.

Warnings & Precautions

Long-term intakes of this amount of Vitamin B6 may lead to mild tingling and numbness.

Not advisable if pregnant or in cases of melanoma, schizophrenia, high blood pressure, or if taking fenfluramine, or MAO inhibitor drugs and exercise care if taking SSRIs.

Rarely, digestive discomfort can occur which usually disappears by reducing the intake. Can cause drowsiness in sensitive individuals; do not drive or operate machinery if affected.

Keep out of reach of children.

Formulation Notes

Glucose is used in the manufacture of this product.

DOES NOT CONTAIN:sugar, salt, starch, soya, wheat, gluten, maize, corn, yeast, lactose, dairy products, artificial preservatives, colours or flavourings.

Suitable for vegetarians and vegans.

B VITAMINS & AMINO ACIDS

VEGETARIAN

Additional Information

This product is not tested on animals.

Jar {Recycle} 1 PET

Lid {Recycle} 5 PP

Charitable organisations policy: supplements regularly donated

PREMIUM NATURALS

Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

B vitamins, tyrosine, glutamine and other nutrients support a happy disposition. This bottle has a UV filter.

Ensure lid is tight and store in a cool, dry, steam-free environment as damp conditions can affect the product quality.

QPO060 106 QPO-274-04

Metadata

Product Details

UPC / SKU5 031013 105050
DSLD Entry Date2014-12-29
Product TypeOther Combinations
FormCapsule
BrandHigher Nature
DSLD ID40911
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
View all evidence for Thiamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.