Positive Outlook by Higher Nature — Ingredients, Evidence & Safety

🟢 97/100

This product looks safe

Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
64% of ingredients have research evidence

C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)

Label Data

2 Capsule(s) Serving Size

Other Combinations Product Type

64% Evidence Coverage

Supplement Facts — Evidence Check

Thiamine

25 mg (2273% DV)

📊 20.8× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 25mg

Niacin

40 mg NE (250% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 1.1× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 40mg UL 35mg

Vitamin B6

20 mg (1429% DV)

📊 15.4× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 20mg UL 100mg

Folic Acid

100 mcg (50% DV)

✅ Within RDA (0.2× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 0.1mg UL 1.0mg

Vitamin B12

10 mcg (400% DV)

📊 4.2× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.01mg

Pantothenic Acid

90 mg (1500% DV)

📊 18.0× RDA — above typical dose 📚 1 studies — no high-quality reviews

RDA 5mg This product: 90mg

Tyrosine

430 mg

📊 Market median: 500.0mg (223 products) 📚 22 studies (Tier A: 0, B: 1)

This product: 430mg

Glutamine

500 mg

📊 Market median: 420.0mg (227 products)

Median 420.0mg This product: 500mg

5-HTP

90 mg

📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)

This product: 90mg

Tri-Methyl Glycine

220 mg

Melissa officinalis

50 mg

Other Ingredients

L-Glutamine L-Tyrosine Betaine Monohydrate Hydroxypropyl Methylcellulose Calcium D-Pantothenate L-5-Hydroxytryptophan Melissa officinalis Niacin Thiamine Hydrochloride Pyridoxine Hydrochloride Magnesium Stearate Silicon Dioxide Folic Acid Methylcobalamin

Label Claims — Verification

❓ All Other

All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Children 4 or More Years of Age Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

DIRECTIONS: Take 2 capsules once or twice a day (children over 6 years, 1 a day), preferably on an empty stomach or with a non-protein snack, or as your health professional advises. Do not exceed recommended daily intake.

⚠️ Warnings & Precautions

Long-term intakes of this amount of Vitamin B6 may lead to mild tingling and numbness.

Not advisable if pregnant or in cases of melanoma, schizophrenia, high blood pressure, or if taking fenfluramine, or MAO inhibitor drugs and exercise care if taking SSRIs.

Rarely, digestive discomfort can occur which usually disappears by reducing the intake. Can cause drowsiness in sensitive individuals; do not drive or operate machinery if affected.

Keep out of reach of children.

🧪 Formulation Notes

Glucose is used in the manufacture of this product.

DOES NOT CONTAIN:sugar, salt, starch, soya, wheat, gluten, maize, corn, yeast, lactose, dairy products, artificial preservatives, colours or flavourings.

Suitable for vegetarians and vegans.

B VITAMINS & AMINO ACIDS

VEGETARIAN

Additional Information

This product is not tested on animals.

Jar {Recycle} 1 PET

Lid {Recycle} 5 PP

Charitable organisations policy: supplements regularly donated

PREMIUM NATURALS

Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

B vitamins, tyrosine, glutamine and other nutrients support a happy disposition. This bottle has a UV filter.

Ensure lid is tight and store in a cool, dry, steam-free environment as damp conditions can affect the product quality.

QPO060 106 QPO-274-04

Product Details

UPC / SKU 5 031013 105050

DSLD Entry Date 2014-12-29

Product Type Other Combinations

Form Capsule

Brand Higher Nature

DSLD ID 40911

Data Updated 2026-04-11

Research Evidence

100 Research Sources

56 Avg Quality Score

48 Systematic Review

30 Meta Analysis

13 Rct

6 Clinical Trial

1 Cochrane Review

1 Regulatory Source

B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol

Systematic Review The Cochrane database of systematic reviews 2013

PubMed DOI Cochrane

B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials

Systematic Review Nutritional neuroscience 2023

PubMed DOI

B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis

Meta Analysis BMJ open 2022

PubMed DOI

B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024

PubMed DOI

B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis

Systematic Review Intensive care medicine 2022

PubMed DOI

B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis

Meta Analysis Pain medicine (Malden, Mass.) 2020

PubMed DOI

B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis

Meta Analysis Critical care medicine 2021

PubMed DOI

B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Complementary therapies in medicine 2022

PubMed DOI

B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023

PubMed DOI

B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse

Systematic Review The Cochrane database of systematic reviews 2004

PubMed Cochrane

View all evidence for Thiamine →