Positive Outlook

product on market Capsule Higher Nature 🟢 Safety: 97/100
Brand: Higher Nature
🟢 97/100

This product looks safe

  • Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
  • 64% of ingredients have research evidence
C Label Compliance Grade

Product Label

Label for Positive Outlook
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Safety Alerts

⚠️ Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)

Label Data

2 Capsule(s) Serving Size
Other Combinations Product Type
64% Evidence Coverage

Supplement Facts — Evidence Check

25 mg (2273% DV)
📊 20.8× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 25mg
40 mg NE (250% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.1× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 40mg UL 35mg
20 mg (1429% DV)
📊 15.4× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 20mg UL 100mg
100 mcg (50% DV)
✅ Within RDA (0.2× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 0.1mg UL 1.0mg
10 mcg (400% DV)
📊 4.2× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.01mg
90 mg (1500% DV)
📊 18.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 90mg
430 mg
📊 Market median: 500.0mg (223 products) 📚 22 studies (Tier A: 0, B: 1)
This product: 430mg
500 mg
📊 Market median: 420.0mg (227 products)
Median 420.0mg This product: 500mg
90 mg
📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)
This product: 90mg
Tri-Methyl Glycine
220 mg
Lemon Balm
50 mg

Other Ingredients

L-Glutamine L-Tyrosine Betaine Monohydrate Hydroxypropyl Methylcellulose Calcium D-Pantothenate L-5-Hydroxytryptophan Lemon Balm Niacin Thiamine Hydrochloride Pyridoxine Hydrochloride Magnesium Stearate Silicon Dioxide Folic Acid Methylcobalamin

Label Claims — Verification

❓ All Other
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Children 4 or More Years of Age Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free Sugar Free

Product Information

📋 Directions for Use

DIRECTIONS: Adults take 2 capsules once or twice a day, children over 6 years, 1 a day, on an empty stomach, or as your health professional advises. Do not exceed recommended daily intake.

⚠️ Warnings & Precautions

WARNING: Not advisable if pregnant or in cases of melanoma, schizophrenia, high blood pressure, or if taking fenfluramine, or MAO inhibitor drugs and exercise care if taking SSRIs.

Rarely, digestive discomfort can occur which usually disappears by reducing the intake. Can cause drowsiness in sensitive individuals; do not drive or operate machinery if affected. Long-term intakes of this amount of Vitamin B6 may lead to mild tingling and numbness.

STORAGE: Store in a cool, dry, steam free environment out of reach of children.

🧪 Formulation Notes

DOES NOT CONTAIN: Artificial colours, flavourings or preservatives, corn, dairy products, gluten, lactose, maize, salt, soya, starch, sugar, wheat, yeast.

Suitable for vegetarians and vegans.

WITH B VITS & AMINO ACIDS

Additional Information

This product is not tested on animals.

{Recycle}

ULTIMATE NUTRITION

Vitamins B6, B12, Thiamine & Niacin support normal function of the nervous system. Vits B6, B12, Niacin, Folate & Pantothenic Acid support normal psychological function & help reduce tiredness & fatigue. Vitamin B6 helps regulate hormonal activity.

Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

STORAGE: Store in a cool, dry, steam free environment out of reach of children.

QPO030 112 QPO-274-04

Product Details

UPC / SKU 5 031013 104688
DSLD Entry Date 2014-12-29
Product Type Other Combinations
Form Capsule
Brand Higher Nature
DSLD ID 40910
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
PubMed DOI Cochrane
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
PubMed Cochrane
View all evidence for Thiamine →

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