🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 62% of ingredients have research evidence
A Label Compliance Grade

Product Label

📸

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Label Data

4 Capsule(s) Serving Size
Other Combinations Product Type
62% Evidence Coverage

Supplement Facts — Evidence Check

1500 mcg (25000% DV)
📊 625.0× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 1.5mg
📊 Market median: 200.0mg (198 products) 📚 6 studies — no high-quality reviews
This product: 1200mg
Borage Oil Powder
500 mg
200 mg
📊 166.7× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 200mg
📊 Market median: 500.0mg (861 products) 📚 60 studies (Tier A: 4, B: 13)
This product: 20mg
📊 Market median: 120.0mg (440 products) 📚 187 studies (Tier A: 1, B: 71)
This product: 20mg
20 mg
📊 Market median: 420.0mg (227 products)
Median 420.0mg This product: 20mg
20 mg
📊 Market median: 550.0mg (217 products) 📚 29 studies (Tier A: 0, B: 5)
This product: 20mg

Other Ingredients

Gelatin Microcrystalline Cellulose Magnesium Stearate Silicon Dioxide

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (89% of products) Nutrient (56% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Directions: As a dietary supplement for adults, take 4 capsules daily, preferably with a meal or as directed by a healthcare professional.

⚠️ Warnings & Precautions

WARNING: Consult a healthcare professional before taking this product if you are pregnant or nursing.

Keep out of reach of children.

Additional Information

SPECIALTY FORMULAS

EST 1960

Store at room temperature. Protect from light.

Made in USA

Item No. 651a REF 0514

No. 651a

SUPPORTS HEALTHY NERVE FUNCTION

Product Details

UPC / SKU 7 16563 65101 5
DSLD Entry Date 2014-07-25
Product Type Other Combinations
Form Capsule
DSLD ID 35258
Data Updated 2026-04-11

Research Evidence

237 Research Sources
53 Avg Quality Score
83 Meta Analysis
74 Systematic Review
45 Rct
29 Clinical Trial
2 Guideline
2 Regulatory Source
1 Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023
View all evidence for Vitamin B12 →

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