Home/ Supplements/ Folate/ Methylfolate B Complex+

Methylfolate B Complex+

product on market Capsule Codeage Safety: 92/100
92/100

This product looks safe

  • Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)
  • 80% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This profile contains B vitamins and betaine, which are supported by strong evidence for supporting energy metabolism and homocysteine regulation. Research indicates these nutrients play critical roles in cellular function and neurological health. The evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1360mg is 1360.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Methylfolate B Complex+
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
80%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

30 mg (2308% DV)
23.1× RDA — above typical dose 13 studies (A:0, B:1)
15 mg (882% DV)
11.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
1360 mcg DFE (340% DV)
Exceeds UL by 1360.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
1000 mcg (41667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)
600 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Methylcellulose
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: Adults take 2 capsules daily, or as recommended by your healthcare practitioner, with 8 ounces of water or your favorite beverage. May be taken with or without food.

Warnings & Precautions

Caution: Do not exceed recommended dose. Discontinue use two weeks prior to surgery.

Pregnant or nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Please use caution if you have allergies or sensitivities to any of the listed ingredients.

Do not use if product has been opened or tampered with in any way.

Keep out of reach of children and pets.

Formulation Notes

B-Complex Quatrefolic Methylcobalamin 5-MTHF - Betaine - Riboflavin B2, B6, B9, B12

Non-GMO Soy-Free Dairy-Free Gluten-Free

cGMP Certified Manufacturing Bioavailable

Additional Information

2-Month Supply Codeage Feel Different.

Scan for info Please recycle Bottle & Cap Please take off the label Questions? Codeage.com

Store in a cool, dry place.

Mb 25.2002.10

Metadata

Product Details

UPC / SKU8 53919 00859 5
DSLD Entry Date2025-06-25
Product TypeOther Combinations
FormCapsule
BrandCodeage
DSLD ID335376
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.