Home/ Supplements/ 5 Htp/ Mood Positive 5-HTP

Mood Positive 5-HTP

product on market Tablet or Pill Natrol Safety: 94/100
94/100

This product looks safe

  • Folate: 340mg is 340.0× the Tolerable Upper Intake Level (1.0mg)
  • 83% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

5-HTP is supported by moderate evidence for promoting serotonin synthesis, while B vitamins and folate serve as essential cofactors for neurotransmitter production. Calcium supports general neurological function and cellular signaling. Research indicates these ingredients are generally well-tolerated, reflecting a high safety score for most users.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 340mg is 340.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Mood Positive 5-HTP
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
50
Servings
Other Combinations
Product Type
83%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

10 mg (588% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
340 mcg DFE (85% DV)
Exceeds UL by 340.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
50 mcg (2083% DV)
20.8× RDA — above typical dose 139 studies (A:1, B:44)
Calcium
135 mg (10% DV)
50 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
50 mg
Market median: 200.0mg (358 products) 9 studies (A:0, B:2)

Other Ingredients

Microcrystalline Cellulose Stearic Acid Silicon Dioxide Magnesium Stearate Cellulose Gum Methylcellulose Glycerin
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Adults, take 1 tablet 1-2 times daily with a meal.

Warnings & Precautions

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, or are taking medication or have a medical condition; including drugs for depression, migraines, Parkinson's disease or psychiatric disorders.

Warning: Consult a healthcare professional before using this product if you are pregnant, nursing, under the age of 18, or are taking medication or have a medical condition; including drugs for depression, migraines, Parkinson's disease or psychiatric disorders. Keep out of reach of children.

Do not use with other supplements containing L-Tryptophan or 5-HTP. If adverse reactions occur, discontinue use.

Do not use if safety seal is damaged or missing.

Formulation Notes

Natrol Mood Positive 5-HTP: Helps support a balanced mood Vitamin B6, Vitamin B12 and Folic Acid support brain and neurological health

Mood + stress

100% Drug free

5-HTP promotes production of serotonin, which is associated with general well-being L-Theanine supports alpha brain wave formation, which is associated with relaxation

No: Milk, egg, fish, crustacean shellfish, tree nuts, peanuts, wheat, soybeans, sesame.

Additional Information

Store in a cool, dry place.

Metadata

Product Details

UPC / SKU0 47469 05233 1
DSLD Entry Date2025-06-25
Product TypeOther Combinations
FormTablet or Pill
BrandNatrol
DSLD ID332299
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.