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5-HTP Mood & Relaxation 100 mg

product on market Tablet or Pill Natrol Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

5-HTP is a precursor to serotonin and is used to support mood and relaxation. There is moderate research evidence suggesting its efficacy in managing symptoms of depression and sleep quality. The ingredient profile maintains a high safety score for general use.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for 5-HTP Mood & Relaxation 100 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Amino acid/Protein
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

100 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)

Other Ingredients

Cellulose Dibasic Calcium Phosphate Hypromellose Silica Stearic Acid Magnesium Stearate Methylcellulose Glycerin
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 1 tablet, up to two times daily, with a meal.

Warnings & Precautions

Do not use with other supplements containing L-tryptophan or 5-HTP.

Do not use if you are pregnant, lactating or under the age of 18 years.

Consult your healthcare professional prior to use if you have or suspect a medical condition or are taking prescription drugs, including drugs for depression, migraines, Parkinson's disease, or psychiatric disorders.

Do not use if you are pregnant, lactating or under the age of 18 years.

KEEP OUT OF REACH OF CHILDREN.

Formulation Notes

100% Drug Free

100% Vegetarian.

No Yeast, Wheat, Corn, Milk, Egg, Soy, Glutens, Artificial Colors or Flavors, Added Sugar or Preservatives.

Additional Information

Mood Support

12-Hour Time Release Formula Promotes Calm & Relaxed Mood Helps Control Appetite

5-HTP has been the subject of extensive clinical research demonstrating its beneficial effects on mood.

ITEM: 447497 F: 3001864 S: 2006476-11151

STORE IN A COOL, DRY PLACE.

JUL 2013

Metadata

Product Details

UPC / SKU0 47469 05691 9
DSLD Entry Date2013-10-25
Product TypeAmino acid/Protein
FormTablet or Pill
BrandNatrol
DSLD ID26953
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.