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Vitamin B12 250

product on market Capsule ProCaps Safety: 97/100
97/100

This product looks safe

  • Folate: 33mg is 33.0× the Tolerable Upper Intake Level (1.0mg)
  • 73% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

This formula contains a blend of B-vitamins and Vitamin C, which are supported by strong evidence for their roles in energy metabolism and immune function. The ingredients generally maintain a high safety profile, though the overall evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 33mg is 33.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Vitamin B12 250
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
720
Servings
Multi-Vitamin and Mineral (MVM)
Product Type
73%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin C
60 mg (67% DV)
5 mg (417% DV)
4.2× RDA — above typical dose 76 studies (A:0, B:33)
5 mg (385% DV)
3.8× RDA — above typical dose 13 studies (A:0, B:1)
5 mg (31% DV)
Within RDA (0.4× RDA) 196 studies (A:5, B:63)
5 mg (100% DV)
Within RDA (1.0× RDA) 2 studies — no high-quality reviews
5 mg (294% DV)
3.8× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
250 mcg (10417% DV)
104.2× RDA — above typical dose 139 studies (A:1, B:44)
33 mcg DFE (8% DV)
Exceeds UL by 33.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
50 mcg (167% DV)
1.7× RDA — within safe limits 27 studies (A:0, B:11)
Calcium
60 mg (5% DV)
30 mg (7% DV)
Within RDA (0.1× RDA) 316 studies (A:8, B:159)

Other Ingredients

Gelatin Proprietary Protective Methyl B12 Matrix
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use Consume one capsule daily. You can increase your intake as required or as guided by your physician.

Formulation Notes

Since 1979, unsurpassed purity, quality and efficacy. 100% solar production Zero carbon footprint

100% solar Protected for optimum absorption

250 mcg natural methyl B12 + complete B-complex

Vitamin B12 250 delivers an exceptionally high potency (250 mcg) of our unique absorption-protected methylcobalamin (natural coenzyme Vitamin B12). Among the B-vitamins, B12 is not just the most important from a functional standpoint, but also because of its limited availability from the diet and extremely difficult absorption. Vitamin B12's challenged absorption stems from its unusually large size and complex molecular structure. Vitamin B12 is essential for energy production, including carbohydrate and fat metabolism, as well as the creation of hemoglobin, without which, vital oxygen cannot be transported throughout the body. Vitamin B12 is also required for the synthesis of our genetic material (DNA and RNA) and is therefore required for normal cell growth and development. Vitamin B12 supports heart and brain health by supporting homocysteine metabolism. Typical supplements deliver Vitamin B12 in the highly inferior, unnatural form of cyanocobalamin. As its name implies, cyanocobalamin can deliver trace amounts of cyanide – an undesirable toxic chemical. No quality product would use cyanocobalamin. The large molecular size of Vitamin B12 makes it highly susceptible to destruction in the digestive system, which is why our natural methylcobalamin is protected from stomach acid so it can release its benefits in the small intestine where it can be absorbed. It is the most intelligent and effective way to orally deliver B12's benefits. It is well-established that stress, aging and digestive issues reduce B12's already poor absorption, so given its critical functions, one should carefully consider supplementing this difficult to find and hard to absorb vitamin. Our vitamin B12 250 overcomes all of the problems of typical B12 supplements and insures the benefits you seek in a small, easy-to-swallow capsule that is gentle to even sensitive stomachs.

Contains no additives or common allergens Contains no milk, soy, yeast, corn, wheat, gluten, sodium, salt, sugar, fat, cholesterol, color, preservative, common allergens, genetically modified (GMO) ingredients or manufacturing additives.

Additional Information

Questions? Reorders? 800.800.1200 www.procapslabs.com Andrew Lessman

Metadata

Product Details

UPC / SKU527257
DSLD Entry Date2025-05-21
Product TypeMulti-Vitamin and Mineral (MVM)
FormCapsule
BrandProCaps
DSLD ID331615
Data Updated2026-04-11
Research

Research Evidence

237
Research Sources
53
Avg Quality
83
Meta Analysis
74
Systematic Review
45
Rct
29
Clinical Trial
2
Guideline
2
Regulatory Source
1
Openfda Safety
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
A Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression
Meta Analysis Nutrients 2021 PubMed DOI
A Efficacy of different routes of vitamin B12 supplementation for the treatment of patients with vitamin B12 deficiency: A systematic review and network meta-analysis
Systematic Review Irish journal of medical science 2024 PubMed DOI
B Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis
Meta Analysis BMJ open gastroenterology 2020 PubMed DOI
B Vitamin B12 supplementation during pregnancy for maternal and child health outcomes
Systematic Review The Cochrane database of systematic reviews 2024 PubMed DOI
B A comprehensive review and meta-regression analysis of randomized controlled trials examining the impact of vitamin B12 supplementation on homocysteine levels
Meta Analysis Nutrition reviews 2024 PubMed DOI
B Relationship between vitamin B12 levels and motor development: A systematic review
Systematic Review Clinical nutrition ESPEN 2024 PubMed DOI
B Vitamin B12, folate, and homocysteine in metabolic syndrome: a systematic review and meta-analysis
Meta Analysis Frontiers in endocrinology 2023 PubMed DOI
View all evidence for Vitamin B12 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.