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Lean 40

product on market Capsule First Choice Supplements Safety: 0/100
0/100

Safety concerns found

  • Ephedra vulgaris is banned by the FDA — any amount is unsafe
  • 31% of ingredients have research evidence
F Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Caffeine and Vitamin B12 have moderate evidence for supporting energy and alertness. However, the inclusion of 1,3-Dimethylamylamine and Ephedra vulgaris raises significant safety concerns due to potential cardiovascular risks. Overall evidence coverage for this specific profile is very limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Ephedra vulgaris is banned by the FDA — any amount is unsafe

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because it contains Ephedra vulgaris, an ingredient that is banned by the FDA and considered unsafe.

Label

Product Label

Label for Lean 40
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
31%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 180.0mg (239 products) 49 studies (A:1, B:19)
75 mg
31250.0× RDA — above typical dose 139 studies (A:1, B:44)
1,3-Dimethylamylamine
40 mg
Banned by FDA — any amount is unsafe 8 studies — no high-quality reviews
Grains of Paradise
50 mg
Cocoa Seed Extract
25 mg
Theobroma grandiflorum
25 mg
Noopept
10 mg
33 mg
Market median: 983.0mg (16 products) 7 studies (A:0, B:1)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
Market median: 500.0mg (223 products) 24 studies (A:0, B:1)
Ghost Pepper extract
11 mg
Piperine
10 mg
10 mg
Within RDA (0.7× RDA) 196 studies (A:5, B:63)
Alpha Yohimbine
2 mg
3,5-Diiodo-L-Thyronine
200 mcg
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Formulation Notes

Thermogenic Explosive energy Raw vascularity Razor sharp focus God like strength

Metadata

Product Details

DSLD Entry Date2025-01-23
Product TypeOther Combinations
FormCapsule
BrandFirst Choice Supplements
DSLD ID326022
Data Updated2026-04-11
Research

Research Evidence

82
Research Sources
51
Avg Quality
28
Rct
19
Meta Analysis
17
Clinical Trial
16
Systematic Review
A Preconception lifestyle advice for people with infertility
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
B Effects of caffeine chewing gum supplementation on exercise performance: A systematic review and meta-analysis
Meta Analysis European journal of sport science 2023 PubMed DOI
B Genetic susceptibility to caffeine intake and metabolism: a systematic review
Systematic Review Journal of translational medicine 2024 PubMed DOI
B Pharmacological interventions for sleepiness and sleep disturbances caused by shift work
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
B Effects of Caffeine Intake on Endurance Running Performance and Time to Exhaustion: A Systematic Review and Meta-Analysis
Meta Analysis Nutrients 2022 PubMed DOI
B The effects of green tea extract supplementation on body composition, obesity-related hormones and oxidative stress markers: a grade-assessed systematic review and dose-response meta-analysis of randomised controlled trials
Meta Analysis The British journal of nutrition 2024 PubMed DOI
B Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis
Systematic Review The American journal of clinical nutrition 2010 PubMed DOI
B Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes
Rct Medicine and science in sports and exercise 2018 PubMed DOI
B The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness
Rct Nutritional neuroscience 2010 PubMed DOI
View all evidence for Caffeine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.