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Methyl-Plex B

product on market Capsule NuMedica Safety: 92/100
92/100

This product looks safe

  • Folate: 2040mg is 2040.0× the Tolerable Upper Intake Level (1.0mg)
  • 80% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains B vitamins and trimethylglycine, which are supported by strong evidence for their roles in energy metabolism and methylation processes. These ingredients facilitate the conversion of homocysteine to methionine in the body. However, overall evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 2040mg is 2040.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Methyl-Plex B
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
80%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

25 mg (1923% DV)
19.2× RDA — above typical dose 13 studies (A:0, B:1)
25 mg (1471% DV)
19.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
2040 mcg DFE (510% DV)
Exceeds UL by 2040.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
1000 mcg (41667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Hydroxypropyl Methylcellulose Microcrystalline Cellulose Magnesium Stearate Silicon Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take one capsule once per day with a meal or as directed by your healthcare practitioner.

Warnings & Precautions

Caution: Keep out of reach of children.

Formulation Notes

Methyl-Plex B is a comprehensive formula designed to support healthy homocysteine levels and optimal methylation. B vitamins are provided in their active forms to support enhanced methylation and cardiovascular health.

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy. Sourced from non-GMO ingredients.

Activated B-Vitamins

Professional Quality Formulas

Supports healthy homocysteine levels Supports optimal methylation

GF Gluten-Free

Vegetarian

Additional Information

Storage: Keep tightly closed in a cool, dry place

cGMP Third-Party Certified Facility

Metadata

Product Details

UPC / SKU8 12527 01076 5
DSLD Entry Date2025-01-23
Product TypeOther Combinations
FormCapsule
BrandNuMedica
DSLD ID323580
Data Updated2026-04-11
Research

Research Evidence

22
Research Sources
49
Avg Quality
8
Rct
4
Meta Analysis
4
Clinical Trial
3
Systematic Review
1
Cochrane Review
1
Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024 PubMed DOI
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022 PubMed DOI
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010 PubMed DOI
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews PubMed DOI
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022 PubMed DOI
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017 PubMed DOI
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010 PubMed DOI
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023 PubMed DOI
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014 PubMed DOI
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.