Methyl-Plex B by NuMedica — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

⚠️ Folate: 2040mg is 2040.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size

60 Servings

Other Combinations Product Type

80% Evidence Coverage

Supplement Facts — Evidence Check

Riboflavin

25 mg (1923% DV)

📊 19.2× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 25mg

Vitamin B6

25 mg (1471% DV)

📊 19.2× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 25mg UL 100mg

Folate

2040 mcg DFE (510% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 2040.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 2040mg UL 1.0mg

Vitamin B12

1000 mcg (41667% DV)

📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 1.0mg

Trimethylglycine

500 mg

📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews

This product: 500mg

Other Ingredients

Hydroxypropyl Methylcellulose Microcrystalline Cellulose Magnesium Stearate Silicon Dioxide

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (85% of products) Nutrient (48% of products) No Claim (1% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Take one capsule once per day with a meal or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: Keep out of reach of children.

🧪 Formulation Notes

Methyl-Plex B is a comprehensive formula designed to support healthy homocysteine levels and optimal methylation. B vitamins are provided in their active forms to support enhanced methylation and cardiovascular health.

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy. Sourced from non-GMO ingredients.

Activated B-Vitamins

Professional Quality Formulas

Supports healthy homocysteine levels Supports optimal methylation

GF Gluten-Free

Vegetarian

Additional Information

Storage: Keep tightly closed in a cool, dry place

cGMP Third-Party Certified Facility

Product Details

UPC / SKU 8 12527 01076 5

DSLD Entry Date 2025-01-23

Product Type Other Combinations

Form Capsule

Brand NuMedica

DSLD ID 323580

Data Updated 2026-04-11

Research Evidence

22 Research Sources

49 Avg Quality Score

8 Rct

4 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Cochrane Review

1 Regulatory Source

B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis

Systematic Review BMJ open 2024

PubMed DOI

B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis

Meta Analysis Nutritional neuroscience 2022

PubMed DOI

B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries

Systematic Review The Cochrane database of systematic reviews 2010

PubMed DOI Cochrane

B Riboflavin supplements for blood pressure lowering in adults.

Cochrane Review The Cochrane database of systematic reviews

PubMed DOI Cochrane

B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis

Meta Analysis Nutrition reviews 2022

PubMed DOI

C Prophylaxis of migraine headaches with riboflavin: A systematic review

Systematic Review Journal of clinical pharmacy and therapeutics 2017

PubMed DOI

C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial

Rct Cephalalgia : an international journal of headache 2010

PubMed DOI

C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis

Meta Analysis International ophthalmology 2023

PubMed DOI

C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis

Meta Analysis The ocular surface 2014

PubMed DOI

C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial

Rct The journal of headache and pain 2015

PubMed DOI

View all evidence for Riboflavin →