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Double Potency 5-HTP Extra

product on market Softgel Capsule Irwin Naturals Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 40% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

The listed ingredients, including Vitamin D, are primarily basic nutrients with strong evidence for supporting bone health and immune function. However, the evidence coverage for this specific profile is very low at 0.4%. There is limited research available to support the combined efficacy of these specific components for the product's intended purpose.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Double Potency 5-HTP Extra
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Liquid Soft-Gel(s)
Serving Size
30
Servings
Other Combinations
Product Type
40%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Calories
15 Calorie(s)
Total Fat
1 Gram(s) (1% DV)
Cholesterol
10 mg (3% DV)
Total Carbohydrates
1 Gram(s) (1% DV)
12.5 mcg (63% DV)
Within RDA (0.8× RDA) 608 studies (A:16, B:251)
10 mg (588% DV)
7.7× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
50 mg (12% DV)
Within RDA (0.1× RDA) 316 studies (A:8, B:159)
800 mg
Market median: 750.0mg (447 products) 393 studies (A:18, B:204)
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
Lemon Balm Leaf Extract
100 mg
100 mg
Market median: 200.0mg (358 products) 9 studies (A:0, B:2)
Damiana Leaf Extract
75 mg
Market median: 500.0mg (138 products) 2 studies — no high-quality reviews
Saffron Flower, Stigma Extract
5 mg
BioPerine Complex
3 mg

Other Ingredients

Gelatin Water, Purified Glycerin Beeswax Soy Lecithin Turmeric Titanium Dioxide Silicon Dioxide Sodium Copper Chlorophyllin Maltodextrin
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: (Adult) Take two (2) liquid soft-gels twice daily with meals.

Warnings & Precautions

Usage warnings: Do not use if safety seal is broken. Some people may experience drowsiness. Exercise caution if driving a vehicle or operating machinery. Do not exceed recommended daily intake. Warning: (State of California Prop 65) This product contains a chemical known to the State of California to cause birth defects or other reproductive harm.

Check with your doctor before using this product if you are using medication, including anti-depressants and pain medication, or have any medical conditions, including digestive disorders. Do not use if you may become pregnant, are pregnant or nursing.

Not intended for use by persons under 18. Keep out of reach of children.

Contains: Fish (anchovy, sardine), soy

Formulation Notes

Double Potency 5-HTP Extra is a comprehensive formula designed to support mood and relaxation. Central to this formulation is 5-Hydroxytryptophan (5-HTP), a naturally occurring amino acid that is the immediate precursor of Serotonin. This plant derived compound sourced from the Griffonia simplicifolia, a climbing shrub native to West and Central Africa, helps the body to naturally produce this hormone, helping you attain an improved state of well-being. To complement the benefits of 5-HTP , this product also features L-Theanine that helps to increase alpha brain waves thereby supporting relaxation of the mind and body. This product also includes other botanicals such as Holy Basil and Damiana that have been used in traditional mood formulas and are known for their adaptogenic properties.

This product can be taken daily to help support mood and relaxation, and in doing so, helps promote a more balanced state of mind. What makes us different: Liquid Soft-Gels - The nutrients in these easy-to-swallow liquid soft-gels are released fast. Other forms of delivery can contain binders and fillers that may cause stomach upset and offer no traditional value. Advanced Liquid Soft-Gels provide an optimum delivery system. Quality assurance - Irwin Naturals is committed to providing the highest quality products for your health. We employ compliance testing to ensure purity and potency. Patented BioPerine - Our special BioPerine Complex enhances the bioavailability, absorption and potency of many nutrients.

Mood & relaxation

5-HTP for Serotonin Production Plus L-theanine, lemon balm, saffron and holy basil.

No preservatives added.

Additional Information

Global responsibility - Over the years we have donated to organizations that support the environment and the health of children.

Pass Quality Tested Guaranteed

Store in a cool, dry place.

Questions: Contact consumer affairs Weekdays 8:00 AM to 5:00 PM (PST) 100+ highly specialized products: www.IrwinNaturals.com

Full Disclosure Ingredient Panel

Metadata

Product Details

UPC / SKU7 10363 58537 2
DSLD Entry Date2025-01-23
Product TypeOther Combinations
FormSoftgel Capsule
DSLD ID323281
Data Updated2026-04-11
Research

Research Evidence

21
Research Sources
53
Avg Quality
11
Systematic Review
6
Rct
4
Meta Analysis
B Combination pharmacotherapy for the treatment of fibromyalgia in adults
Systematic Review The Cochrane database of systematic reviews 2018 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial
Rct Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial
Rct Nutrients 2025 PubMed DOI
B The Efficacy of Different Triptans for the Treatment of Acute Headache in Pediatric Migraine: A Systematic Review
Systematic Review Indian pediatrics 2023 PubMed
B The effect of therapeutic massage combined with conventional therapy in children with functional dyspepsia: a systematic review and meta-analysis
Systematic Review Frontiers in pharmacology 2025 PubMed DOI
C Sleep disorders in children
Systematic Review BMJ clinical evidence 2010 PubMed
C Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2020 PubMed DOI
C Investigating genetic links between biological aging and adverse pregnancy outcomes
Meta Analysis Biogerontology 2025 PubMed DOI
View all evidence for 5 Htp →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.