Optimal Sleep II by Seeking Health — Ingredients, Evidence & Safety

🟢 100/100

This product looks safe

No ingredients exceed tolerable upper intake levels
80% of ingredients have research evidence

A Label Compliance Grade

Product Label

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Label Data

2 Capsule(s) Serving Size

30 Servings

Botanical with Nutrients Product Type

80% Evidence Coverage

Supplement Facts — Evidence Check

Thiamine

5 mg (417% DV)

📊 4.2× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 5mg

Riboflavin

5 mg (385% DV)

📊 3.8× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 5mg

Niacin

15 mg (94% DV)

✅ 1.1× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 15mg UL 35mg

Vitamin B6

5 mg (294% DV)

📊 3.8× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 5mg UL 100mg

Magnesium

125 mg (30% DV)

📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)

This product: 125mg

Zinc

7 mg (64% DV)

✅ Within RDA (0.6× RDA of 11 mg) 📚 258 studies (Tier A: 6, B: 134)

RDA 11mg This product: 7mg UL 40mg

L-Ornithine Hydrochloride

160 mg

📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)

This product: 160mg

KSM-66

125 mg

📊 Market median: 450.0mg (502 products) 📚 28 studies (Tier A: 0, B: 8)

This product: 125mg

Phosphatidylserine

25 mg

📊 Market median: 100.0mg (108 products)

Median 100.0mg This product: 25mg

Lithium

2.5 mg

Other Ingredients

Hypromellose Water Ascorbyl Palmitate

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested use: Take 2 capsules away from food 30 minutes prior to bedtime, or use as directed by your healthcare professional.

⚠️ Warnings & Precautions

Children and pregnant or lactating women should consult their healthcare professional prior to use. Storage: Keep closed in a cool, dry place out of reach of children.

Children and pregnant or lactating women should consult their healthcare professional prior to use.

Do not use if tamper seal is damaged.

🧪 Formulation Notes

Optimal Sleep II supports healthy onset of sleep by helping to balance glutamate (a stimulating neurotransmitter) and GABA (a calming neurotransmitter.) This formula also supports the metabolism of serotonin, dopamine, norepinephrine, and epinephrine, as well as healthy evening cortisol levels. This product is intended to support occasional sleeplessness.

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy, gluten, GMO, artificial colors, or artificial flavors.

Optimal Sleep II meets or exceeds cGMP Quality Standards.

Manufactured in the USA from globally sourced ingredients Third-party independently tested

Optimal Sleep II with B1, B2, Ornithine, and Lithium

Free of 5-HTP

Additional Information

Storage: Keep closed in a cool, dry place out of reach of children.

Find other effective health products at: www.seekinghealth.com This package is completely recyclable

Product Details

UPC / SKU 8 10007 52167 1

DSLD Entry Date 2024-12-21

Product Type Botanical with Nutrients

Form Capsule

Brand Seeking Health

DSLD ID 322695

Data Updated 2026-04-11

Research Evidence

100 Research Sources

56 Avg Quality Score

48 Systematic Review

30 Meta Analysis

13 Rct

6 Clinical Trial

1 Cochrane Review

1 Regulatory Source

B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol

Systematic Review The Cochrane database of systematic reviews 2013

PubMed DOI Cochrane

B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials

Systematic Review Nutritional neuroscience 2023

PubMed DOI

B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis

Meta Analysis BMJ open 2022

PubMed DOI

B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024

PubMed DOI

B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis

Systematic Review Intensive care medicine 2022

PubMed DOI

B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis

Meta Analysis Pain medicine (Malden, Mass.) 2020

PubMed DOI

B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis

Meta Analysis Critical care medicine 2021

PubMed DOI

B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Complementary therapies in medicine 2022

PubMed DOI

B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023

PubMed DOI

B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse

Systematic Review The Cochrane database of systematic reviews 2004

PubMed Cochrane

View all evidence for Thiamine →