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Focus Now

product on market Capsule Rise-N-Shine Safety: 86/100
86/100

This product is generally safe

  • Folate: 670mg is 670.0× the Tolerable Upper Intake Level (1.0mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 80% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This product contains a blend of B vitamins that support cellular energy metabolism and neurological function. There is strong evidence for the role of these nutrients in maintaining cognitive health, though the overall evidence coverage for this specific formulation is limited. The ingredient profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 670mg is 670.0× the Tolerable Upper Intake Level (1.0mg)

Contains proprietary blend — exact ingredient amounts not disclosed

Label

Product Label

Label for Focus Now
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
80%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1.5 mg (125% DV)
1.2× RDA — within safe limits 76 studies (A:0, B:33)
1.7 mg (131% DV)
1.3× RDA — within safe limits 13 studies (A:0, B:1)
30 mg (188% DV)
2.1× RDA — within safe limits 196 studies (A:5, B:63)
40 mg (2353% DV)
30.8× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
670 mcg DFE (167% DV)
Exceeds UL by 670.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
500 mcg (20833% DV)
208.3× RDA — above typical dose 139 studies (A:1, B:44)
100 mcg (333% DV)
3.3× RDA — above typical dose 27 studies (A:0, B:11)
10 mg (200% DV)
2.0× RDA — within safe limits 2 studies — no high-quality reviews
100 mg (24% DV)
Within RDA (0.2× RDA) 316 studies (A:8, B:159)
Proprietary Blend
330 mg

Other Ingredients

Rice Flour Bovine Gelatin Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: 1 capsule, taken 1 to 2 times daily with meals or as directed by a healthcare professional. This product should be used in conjunction with a sensible diet and exercise program.

Warnings & Precautions

Caution: As with any dietary supplement, check with your physician before taking this product. Do not exceed recommended dose. Notice: Most people should not experience "niacin skin flush" when using this product. However a few sensitive individuals may experience some flushing. Do not take on an empty stomach. Do not use if safety seal is damaged or missing. Warning: This product contains 100 mg of caffeine per serving (equivalent to approximately 1 cup of coffee).

This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish and crustacean shellfish.

Keep out of reach of children.

Formulation Notes

Contains natural and synthetic/artificial ingredients.

Premium concentration formula

Results may vary.

Additional Information

Store in a cool, dry place

Formulated in the USA

GMP Quality Good Manufacturing Practice Certification

Metadata

Product Details

UPC / SKU8 50046 24408 7
DSLD Entry Date2024-05-23
Product TypeOther Combinations
FormCapsule
BrandRise-N-Shine
DSLD ID313441
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
View all evidence for Thiamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.