Methylation Protect

product on market Capsule Adaptogen Research 🟢 Safety: 92/100
Brand: Adaptogen Research
🟢 92/100

This product looks safe

  • Folate: 3.4mg is 3.4× the Tolerable Upper Intake Level (1.0mg)
  • 80% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 3.4mg is 3.4× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size
120 Servings
Other Combinations Product Type
80% Evidence Coverage

Supplement Facts — Evidence Check

25 mg (1923% DV)
📊 19.2× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 25mg
10 mg (588% DV)
📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 10mg UL 100mg
3400 mcg (850% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 3.4× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 3.4mg UL 1.0mg
1000 mcg (41667% DV)
📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 1.0mg
500 mg
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 500mg

Other Ingredients

Hypromellose Water Stearic Acid Microcrystalline Cellulose Silica Magnesium Stearate Medium Chain Triglyceride Oil

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (85% of products) Nutrient (48% of products) No Claim (1% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: take one capsule one to two times daily, or as directed by your healthcare professional.

⚠️ Warnings & Precautions

Consult your healthcare professional prior to use. Do not use if tamper seal is damaged.

Report any adverse reaction on adaptogenresearch.com

Professional use only

Individuals taking medication should discuss potential interactions with their healthcare professional.

Storage: Keep closed in a cool, dry place out of reach of children.

🧪 Formulation Notes

Methylation Protect NAC FREE is a comprehensive formula designed to support optimal methylation and help maintain healthy homocysteine levels already within normal range.

It features five key nutrients that are involved in homocysteine metabolism: folate as calcium folinate and Quatrefolic for increased bioactivity; trimethylglycine; and vitamins B12, B6, and B2. These five nutrients, provided in activated forms, support enhanced methylation and overall cardiovascular health.

Formulated to exclude: wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

Vegetarian formula

Made with non-GMO ingredients Does not contain gluten NAC Free

Vegetarian caps

Additional Information

Storage: Keep closed in a cool, dry place out of reach of children.

Guaranteed GMP compliant products

This package is completely recyclable

Product Details

UPC / SKU 7 22537 49795 4
DSLD Entry Date 2024-04-23
Product Type Other Combinations
Form Capsule
Brand Adaptogen Research
DSLD ID 307154
Data Updated 2026-04-11

Research Evidence

22 Research Sources
49 Avg Quality Score
8 Rct
4 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Cochrane Review
1 Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024
PubMed DOI
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022
PubMed DOI
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010
PubMed DOI Cochrane
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews
PubMed DOI Cochrane
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022
PubMed DOI
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017
PubMed DOI
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010
PubMed DOI
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023
PubMed DOI
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014
PubMed DOI
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015
PubMed DOI
View all evidence for Riboflavin →

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