Methyl B Complete by Pure TheraPro Rx — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

⚠️ Folate: 3400mg is 3400.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size

120 Servings

Other Combinations Product Type

80% Evidence Coverage

Supplement Facts — Evidence Check

Riboflavin

25 mg (1923% DV)

📊 19.2× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 25mg

Vitamin B6

15 mg (882% DV)

📊 11.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 15mg UL 100mg

Folate

3400 mcg DFE (850% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 3400.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 3400mg UL 1.0mg

Vitamin B12

1000 mcg (41667% DV)

📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 1.0mg

Trimethylglycine

650 mg

📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews

This product: 650mg

Other Ingredients

DRcaps Tricalcium Phosphate

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (85% of products) Nutrient (48% of products) No Claim (1% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: take one (1) capsule one to two times daily, or as directed by a healthcare practitioner.

⚠️ Warnings & Precautions

Warning: individuals taking medication, children and pregnant or lactating women should consult their healthcare practitioner prior to use.

Do not use if tamper seal is damaged.

Keep out of reach of children.

🧪 Formulation Notes

Please note: natural color variations from light yellow to bright orange may occur between lots.

Methyl B complete is a cutting-edge formula compromised of 5 key nutrients: quatrefolic folate for maximum MTHFR support, trimethylglycine, a super-bioactive blend of vitamin B12 (including patented mecobalactive methylcobalamin), as well as vitamin B6 in its coenzyme form and the highest-quality vitamin B2 (riboflavin). This synergistic formula is responsible for supporting healthy homocysteine levels, vibrant energy production, optimal detoxification, a robust metabolism, and peak cognitive function.

Formulated to exclude: fillers, gluten, wheat, soy, corn, yeast, animal or dairy products, shellfish, fish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMO's), artificial preservatives, sweeteners or colors.

Vegan

Supports energy production, methylation & detoxification

Formulated, tested & packaged in the USA

Additional Information

Storage: keep tightly closed in a cool, dry place.

For optimal freshness, do not discard desiccant.

Good Manufacturing Practice GMP Certified

Please recycle

Product Details

UPC / SKU X000S6O43B

DSLD Entry Date 2024-01-24

Product Type Other Combinations

Form Capsule

Brand Pure TheraPro Rx

DSLD ID 305957

Data Updated 2026-04-11

Research Evidence

22 Research Sources

49 Avg Quality Score

8 Rct

4 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Cochrane Review

1 Regulatory Source

B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis

Systematic Review BMJ open 2024

PubMed DOI

B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis

Meta Analysis Nutritional neuroscience 2022

PubMed DOI

B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries

Systematic Review The Cochrane database of systematic reviews 2010

PubMed DOI Cochrane

B Riboflavin supplements for blood pressure lowering in adults.

Cochrane Review The Cochrane database of systematic reviews

PubMed DOI Cochrane

B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis

Meta Analysis Nutrition reviews 2022

PubMed DOI

C Prophylaxis of migraine headaches with riboflavin: A systematic review

Systematic Review Journal of clinical pharmacy and therapeutics 2017

PubMed DOI

C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial

Rct Cephalalgia : an international journal of headache 2010

PubMed DOI

C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis

Meta Analysis International ophthalmology 2023

PubMed DOI

C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis

Meta Analysis The ocular surface 2014

PubMed DOI

C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial

Rct The journal of headache and pain 2015

PubMed DOI

View all evidence for Riboflavin →