🟢 97/100

This product looks safe

  • Folate: 430mg is 430.0× the Tolerable Upper Intake Level (1.0mg)
  • 64% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 430mg is 430.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

3.3 Gram(s) Serving Size
90 Servings
Other Combinations Product Type
64% Evidence Coverage

Supplement Facts — Evidence Check

Calories
10 Calorie(s)
Total Carbohydrates
2 Gram(s) (1% DV)
2 mg (167% DV)
✅ 1.7× RDA — within safe limits 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 2mg
3 mg (231% DV)
✅ 2.3× RDA — within safe limits 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 3mg
20 mg NE (125% DV)
✅ 1.4× RDA — within safe limits 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 20mg UL 35mg
6 mg (353% DV)
📊 4.6× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 6mg UL 100mg
430 mcg DFE (108% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 430.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 430mg UL 1.0mg
120 mcg (5000% DV)
📊 50.0× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.12mg
300 mcg (1000% DV)
📊 10.0× RDA — above typical dose 📚 26 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.3mg
20 mg (400% DV)
📊 4.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 20mg
Potassium
95 mg (2% DV)

Other Ingredients

Fructose Glucose Citric Acid Maltodextrin Silicon Dioxide Apple Fiber Apple Pectin Lemon Flavor Stearic Acid Calcium Sulfate Lime flavor

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Vegan Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions for use: Pour 1 level, white bottle capful of powder into the overcap. Add water to the line on the overcap (2 fl oz/60 ml) and stir. As a dietary supplement, take once daily or as directed by your healthcare provider. Maximum absorption occurs when taken on an empty stomach. This product is Isotonic only if the specified amounts of powder and water are used.

⚠️ Warnings & Precautions

Warning: If you are currently using prescription drugs, have an ongoing medical condition or are pregnant or breastfeeding, consult your healthcare provider before using this product.

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

Resale on third-party websites is strictly prohibited unless specifically authorized by Market America or its corporate affiliates. If barcodes are altered or you purchase this product from an unauthorized third-party website, the product is not guaranteed by Market America or its corporate affiliates.

🧪 Formulation Notes

Increases energy Promotes a healthy nervous system, bone marrow and intestinal tract Promotes cardiovascular health May help decrease stress and improve mood

This vegan product contains no added wheat, soy, yeast, gluten, artificial flavor, starch, salt, preservatives or milk.

Vegan

Gluten free

Additional Information

Store in a cool, dry place.

Product Details

UPC / SKU 8 48570 00113 9
DSLD Entry Date 2023-11-22
Product Type Other Combinations
Form Powder
Brand Isotonix
DSLD ID 298757
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
View all evidence for Thiamine →

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