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EstroFactors

product on market Capsule Metagenics Safety: 87/100
87/100

This product is generally safe

  • Folate: 340mg is 340.0× the Tolerable Upper Intake Level (1.0mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 62% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This profile contains B vitamins and antioxidants that support cellular metabolism and antioxidant defense. Research provides strong evidence for the roles of folate and B6 in metabolic processes, though overall evidence coverage for this specific combination is limited. The formulation maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 340mg is 340.0× the Tolerable Upper Intake Level (1.0mg)

Contains proprietary blend — exact ingredient amounts not disclosed

Label

Product Label

Label for EstroFactors
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Vegetarian Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
62%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
750 mcg (83% DV)
36.2 mg (241% DV)
2.4× RDA — within safe limits 179 studies (A:3, B:90)
1 mg (77% DV)
Within RDA (0.8× RDA) 13 studies (A:0, B:1)
50 mg (2941% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
340 mcg DFE (85% DV)
Exceeds UL by 340.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
30 mcg (1250% DV)
12.5× RDA — above typical dose 139 studies (A:1, B:44)
Rice Protein Matrix and Polyphenols
250 mg
Market median: 200.0mg (3 products) 11 studies (A:1, B:3)
Market median: 260.0mg (249 products) 158 studies (A:4, B:61)
N-Acetyl-L-Cysteine
50 mg
Market median: 4002.0mg (1 products) 21 studies (A:0, B:2)
Proprietary Mix
50 mg
Mixed Carotenoids
1.8 mg

Other Ingredients

Microcrystalline Cellulose Hydroxypropyl Methylcellulose Chlorophyllin Gellan Gum Magnesium Stearate Silica
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take two capsules once or twice daily or as directed by your healthcare practitioner.

Warnings & Precautions

Warning: Do not use if pregnant or breastfeeding. Caution: Consult your healthcare practitioner before use if you are taking medications, including birth-control.

Keep out of reach of children.

Tamper Evident: Do not use if safety seal is missing or broken.

Practitioner Exclusive

Formulation Notes

EstroFactors is a unique formula featuring phytonutrients that provide targeted support for healthy estrogen metabolism. Offering highly bioavailable BioResponse DIM which may promote the 2-hydroxy estrone pathway. HMR lignans are also featured to increase the production of enterolactone, which has been associated with reduced aromatase activity.

This product is non-GMO and gluten-free.

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Targeted support for healthy estrogen metabolism.

Additional Information

Storage: Keep tightly closed in a cool, dry place.

Certified Gluten Free GFCO.org (Gluten-Free Certification Organization)

Metadata

Product Details

UPC / SKU7 55571 95222 6
DSLD Entry Date2023-09-25
Product TypeOther Combinations
FormCapsule
BrandMetagenics
DSLD ID295678
Data Updated2026-04-11
Research

Research Evidence

337
Research Sources
54
Avg Quality
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011 PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016 PubMed DOI
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023 PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
View all evidence for Vitamin A →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.