Ceralin Forte by Metagenics — Ingredients, Evidence & Safety

🟢 92/100

This product looks safe

Niacin: 250mg is 7.1× the Tolerable Upper Intake Level (35mg)
Folate: 830mg is 830.0× the Tolerable Upper Intake Level (1.0mg)
100% of ingredients have research evidence

D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 250mg is 7.1× the Tolerable Upper Intake Level (35mg)

⚠️ Folate: 830mg is 830.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

3 Capsule(s) Serving Size

30 Servings

Other Combinations Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Thiamine

30 mg (2500% DV)

📊 25.0× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 30mg

Riboflavin

30 mg (2308% DV)

📊 23.1× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 30mg

Niacin

250 mg (1563% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 7.1× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 250mg UL 35mg

Vitamin B6

25 mg (1471% DV)

📊 19.2× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 25mg UL 100mg

Folate

830 mcg DFE (208% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 830.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 830mg UL 1.0mg

Vitamin B12

500 mg (20833% DV)

📊 208333.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 500mg

N-Acetyl Cysteine

600 mg

📊 Market median: 600.0mg (7 products) 📚 39 studies (Tier A: 2, B: 13)

This product: 600mg

Acetyl-L-Carnitine Hydrochloride

600 mg

📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)

This product: 600mg

Grape Seed Extract

204 mg

📊 Market median: 100.0mg (284 products) 📚 10 studies (Tier A: 0, B: 4)

This product: 204mg

Other Ingredients

Hypromellose Microcrystalline Cellulose Silica Magnesium Stearate

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free

Product Information

📋 Directions for Use

Directions: Take three capsules daily or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: Do not use if pregnant or nursing. If you have a history of kidney stones or seizures, or are taking medication, consult your healthcare practitioner before use.

Maintain adequate fluid intake while taking this product.

Keep out of the reach of children.

Practitioner Exclusive

🧪 Formulation Notes

Ceralin Forte is formulated to provide multidimensional support for brain and nerve health by protecting against oxidative stress, as well as supporting healthy mitochondrial function, methylation, homocysteine metabolism, and circulatory function.

Designed to act within the brain and nervous system, this advanced formula features L-5-MTHF (a bioactive form of folate), NAC, and acetyl-l-carnitine - which research suggests may be able to cross the blood-brain barrier - along with concentrated grape seed extract to support vascular and nerve health.

This product is non-GMO and gluten-free.

Foundation neuroprotection formula

Product Details

UPC / SKU 7 55571 91513 9

DSLD Entry Date 2023-08-23

Product Type Other Combinations

Form Capsule

Brand Metagenics

DSLD ID 295660

Data Updated 2026-04-11

Research Evidence

100 Research Sources

56 Avg Quality Score

48 Systematic Review

30 Meta Analysis

13 Rct

6 Clinical Trial

1 Cochrane Review

1 Regulatory Source

B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol

Systematic Review The Cochrane database of systematic reviews 2013

PubMed DOI Cochrane

B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials

Systematic Review Nutritional neuroscience 2023

PubMed DOI

B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis

Meta Analysis BMJ open 2022

PubMed DOI

B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024

PubMed DOI

B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis

Systematic Review Intensive care medicine 2022

PubMed DOI

B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis

Meta Analysis Pain medicine (Malden, Mass.) 2020

PubMed DOI

B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis

Meta Analysis Critical care medicine 2021

PubMed DOI

B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Complementary therapies in medicine 2022

PubMed DOI

B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023

PubMed DOI

B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse

Systematic Review The Cochrane database of systematic reviews 2004

PubMed Cochrane

View all evidence for Thiamine →