Home/ Supplements/ Riboflavin/ Methyl-Guard Plus

Methyl-Guard Plus

product on market Capsule Thorne Safety: 92/100
92/100

This product looks safe

  • Folate: 5mg is 5.0× the Tolerable Upper Intake Level (1.0mg)
  • 80% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This profile combines B vitamins and betaine, which are supported by strong evidence for their roles in homocysteine metabolism and methylation. These ingredients facilitate the conversion of homocysteine to methionine to support cardiovascular and neurological health. Current research indicates a high safety profile for these nutrients when taken within recommended dosages.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 5mg is 5.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Methyl-Guard Plus
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
80%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

90 mg (6923% DV)
69.2× RDA — above typical dose 13 studies (A:0, B:1)
45 mg (2647% DV)
34.6× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
5 mcg DFE (1250% DV)
Exceeds UL by 5.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
3 mg (125000% DV)
1250.0× RDA — above typical dose 139 studies (A:1, B:44)
1.8 Gram(s)
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

Hypromellose (derived from Cellulose) Capsule Calcium Citrate Calcium Laurate
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Take 1-3 capsules daily or as recommended by your health-care practitioner.

Warnings & Precautions

Tamper evident: Use only of bottle is sealed.

If pregnant, consult your health-care practitioner before using this product.

Formulation Notes

Heart/vessels Mood

Gluten free

Methylation factors

This product uses Gnosis S.p.A.'s L-5-methyltetrahydrofolic acid, glucosamine salt (quatrefolic).

Additional Information

Store tightly sealed in a cool, dry place.

Manufactured in the USA using US & imported ingredients

Metadata

Product Details

UPC / SKU6 93749 78901 7
DSLD Entry Date2023-07-18
Product TypeOther Combinations
FormCapsule
BrandThorne
DSLD ID291788
Data Updated2026-04-11
Research

Research Evidence

22
Research Sources
49
Avg Quality
8
Rct
4
Meta Analysis
4
Clinical Trial
3
Systematic Review
1
Cochrane Review
1
Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024 PubMed DOI
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022 PubMed DOI
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010 PubMed DOI
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews PubMed DOI
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022 PubMed DOI
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017 PubMed DOI
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010 PubMed DOI
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023 PubMed DOI
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014 PubMed DOI
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015 PubMed DOI
View all evidence for Riboflavin →
Compare

Similar Products

Riboflavin
Gematria · Capsule
100
Vitamin B-2 Riboflavin 100 mg
Martin Avenue Pharmacy · Capsule
100
B2 100 mg
Thompson · Capsule
100
Vitamin B-2 100 Milligrams
NutraBio · Capsule
100
Vitamin B2 100 mg
Solgar · Capsule
100
View all Riboflavin products →
Riboflavin research Best Riboflavin All Riboflavin products More from Thorne View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.