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Nicotinamide

product on market Tablet or Pill Acella Pharmaceuticals Safety: 87/100
87/100

This product is generally safe

  • Niacinamide: 750mg is 21.4× the Tolerable Upper Intake Level (35mg)
  • Folate: 850mg is 850.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Niacinamide, zinc, and folate provide moderate evidence for supporting cellular metabolism and skin health. Selenium and copper act as essential trace minerals for antioxidant enzyme function. Overall, clinical evidence for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacinamide: 750mg is 21.4× the Tolerable Upper Intake Level (35mg)

Folate: 850mg is 850.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Nicotinamide
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
60
Servings
Multi-Vitamin and Mineral (MVM)
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

750 mg (4700% DV)
Exceeds UL by 21.4× (UL: 35 mg) 196 studies (A:5, B:63)
27 mg (245% DV)
2.5× RDA — within safe limits 263 studies (A:6, B:134)
850 mcg DFE (210% DV)
Exceeds UL by 850.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
2 mg (220% DV)
2.2× RDA — within safe limits 37 studies (A:0, B:11)
50 mcg (90% DV)
Within RDA (0.9× RDA) 173 studies (A:0, B:67)
100 mcg (290% DV)
2.9× RDA — within safe limits 199 studies (A:1, B:55)

Other Ingredients

Croscarmellose Sodium Magnesium Stearate Methocel K Microcrystalline Cellulose Silicon Dioxide Stearic Acid Hydroxypropylmethylcellulose Titanium Dioxide Triacetin
Claims

Label Claims — Verification

Unverified All Other
Info

Product Information

Directions for Use

Dosage and administration: Take 1-2 tablets daily, as a dietary supplement, as directed by your physician.

Warnings & Precautions

Warnings: If you are pregnant, nursing, or taking medication, consult your doctor before use.

Use only under the advice and supervision of a physician if you have a history of jaundice, liver disease or diabetes. Abnormal liver function tests have been reported in persons taking daily doses of 500 mg or more of nicotinamide. Folate intake should not exceed 250% of the daily value (1,000 mcg).

Keep out of the reach of children.

Do not use if seal under cap is broken or misisng.

Additional Information

Each white-colored, oval-shaped tablet is debossed with "342" on one side and blank on the other. 42192-374-60 Rx only

Store at 20 degrees - 25 degrees C (68 degrees - 77 degrees F); excursions permitted to 15 degrees - 30 degrees C (59 degrees - 86 degrees F). [See USP controlled room temperature.]

The listed product number is not a National Drug Code, but instead has merely been formatted to comply with standard industry practice for pharmacy and insurance computer systems.

Metadata

Product Details

UPC / SKU3 42192 37460 7
DSLD Entry Date2021-12-18
Product TypeMulti-Vitamin and Mineral (MVM)
FormTablet or Pill
BrandAcella Pharmaceuticals
DSLD ID264262
Data Updated2026-04-11
Research

Research Evidence

241
Research Sources
55
Avg Quality
113
Meta Analysis
75
Systematic Review
32
Rct
11
Clinical Trial
3
Other
3
Regulatory Source
1
Cochrane Review
1
Narrative Review
1
Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014 PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024 PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010 PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010 PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014 PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019 PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016 PubMed DOI
View all evidence for Niacin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.