Home/ Supplements/ Vitamin B6/ MTHFR Endure

MTHFR Endure

product on market Capsule Physician Designed Safety: 96/100
96/100

This product looks safe

  • Folate: 100mg is 100.0× the Tolerable Upper Intake Level (1.0mg)
  • 60% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains B vitamins and choline, which are supported by strong evidence for their roles in methylation and energy metabolism. Folate and B12 specifically support cellular function and homocysteine regulation. However, the overall evidence coverage for this specific combination is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 100mg is 100.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for MTHFR Endure
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
60%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

25 mg (1471% DV)
19.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
100 mcg DFE (25% DV)
Exceeds UL by 100.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
1000 mcg (41667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)
125 mg (2500% DV)
25.0× RDA — above typical dose 2 studies — no high-quality reviews
25 mg (5% DV)
Market median: 125.0mg (294 products) 38 studies (A:1, B:7)
5 mg (45% DV)
Within RDA (0.5× RDA) 263 studies (A:6, B:134)
N-Acetyl L-Cysteine
100 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews
Market median: 500.0mg (223 products) 24 studies (A:0, B:1)
L-Serine
50 mg

Other Ingredients

Rice Flour Natural flavor Vegetable Capsules Vegetable Magnesium Stearate
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: As a dietary supplement, take one capsule daily, or as directed by a physician.

Warnings & Precautions

Tamper evident. Do not use if seal is broken.

Keep out of reach of children.

Formulation Notes

Made in the USA

Additional Information

Store in a cool, dry place.

Clinically proven

Metadata

Product Details

UPC / SKU0 607111 482000
DSLD Entry Date2021-08-23
Product TypeOther Combinations
FormCapsule
BrandPhysician Designed
DSLD ID249573
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
Compare

Similar Products

Water Ease
Designs for Health · Capsule
100
Mag Aspartate
Karuna · Capsule
100
Vitamin B-6 50 mg
Kirkman · Capsule
100
Neuro-Balance 620 Milligrams
Montiff · Capsule
100
Vitamin B-6 50 Milligrams
NutraBio · Capsule
100
View all Vitamin B6 products →
Vitamin B6 research Best Vitamin B6 All Vitamin B6 products More from Physician Designed View on NIH DSLD →

This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.