MTHFR Endure
96/100
This product looks safe
- Folate: 100mg is 100.0× the Tolerable Upper Intake Level (1.0mg)
- 60% of ingredients have research evidence
C
Label Compliance Grade
Product Label
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Safety Alerts
⚠️ Folate: 100mg is 100.0× the Tolerable Upper Intake Level (1.0mg)
Label Data
2 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
60%
Evidence Coverage
Supplement Facts — Evidence Check
25 mg
(1471% DV)
📊 19.2× RDA — above typical dose (UL: 100 mg)
📚 113 studies (Tier A: 3, B: 35)
100 mcg DFE
(25% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 100.0× (UL: 1.0 mg)
📚 225 studies (Tier A: 10, B: 105)
1000 mcg
(41667% DV)
📊 416.7× RDA — above typical dose
📚 138 studies (Tier A: 1, B: 44)
125 mg
(2500% DV)
📊 25.0× RDA — above typical dose
📚 1 studies — no high-quality reviews
25 mg
(5% DV)
📊 Market median: 125.0mg (294 products)
📚 36 studies (Tier A: 1, B: 7)
5 mg
(45% DV)
✅ Within RDA (0.5× RDA of 11 mg)
📚 258 studies (Tier A: 6, B: 134)
N-Acetyl L-Cysteine
100 mg
80 mg
📊 Market median: 496.0mg (192 products)
📚 20 studies — no high-quality reviews
50 mg
📊 Market median: 500.0mg (223 products)
📚 22 studies (Tier A: 0, B: 1)
L-Serine
50 mg
Other Ingredients
Rice Flour
Natural flavor
Vegetable Capsules
Vegetable Magnesium Stearate
Label Claims — Verification
❓
All Other
❓
Structure/Function
All Other (98% of products)
Structure/Function (89% of products)
Nutrient (43% of products)
Target Groups
Adult (18 - 50 Years)
Product Information
📋 Directions for Use
Suggested Use: As a dietary supplement, take one capsule daily, or as directed by a physician.
⚠️ Warnings & Precautions
Tamper evident. Do not use if seal is broken.
Keep out of reach of children.
🧪 Formulation Notes
Made in the USA
Additional Information
Store in a cool, dry place.
Clinically proven
Product Details
UPC / SKU
0 607111 482000
DSLD Entry Date
2021-08-23
Product Type
Other Combinations
Form
Capsule
Brand
Physician Designed
DSLD ID
249573
Data Updated
2026-04-11
Research Evidence
153
Research Sources
55
Avg Quality Score
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A
Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
A
Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
A
Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
A
Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
B
Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
B
The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
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