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Positive Outlook

product on market Capsule Higher Nature Safety: 97/100
97/100

This product looks safe

  • Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
  • 64% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains a complex of B vitamins, including thiamine, niacin, and B12, which are essential for energy metabolism and neurological function. There is strong evidence supporting the role of these nutrients in maintaining cognitive health and mood regulation. The ingredient profile is associated with a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)

Label

Product Label

Label for Positive Outlook
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
22.5
Servings
Other Combinations
Product Type
64%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

25 mg (2273% DV)
20.8× RDA — above typical dose 76 studies (A:0, B:33)
40 mg NE (250% DV)
Exceeds UL by 1.1× (UL: 35 mg) 196 studies (A:5, B:63)
20 mg (1429% DV)
15.4× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
100 mcg (50% DV)
Within RDA (0.2× RDA) 226 studies (A:10, B:105)
10 mcg (400% DV)
4.2× RDA — above typical dose 139 studies (A:1, B:44)
90 mg (1500% DV)
18.0× RDA — above typical dose 2 studies — no high-quality reviews
430 mg
Market median: 500.0mg (223 products) 24 studies (A:0, B:1)
500 mg
Market median: 420.0mg (227 products)
90 mg
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
Tri-Methyl Glycine
220 mg
Lemon Balm extract
18 mg

Other Ingredients

L-Glutamine L-Tyrosine Betaine Monohydrate Capsule Vitamin B5 L-5-Hydroxytryptophan Vitamin B3 Vitamin B1 Vitamin B6 Magnesium Stearate Lemon Balm extract Silicon Dioxide Folic Acid Vitamin B12
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take 2 capsules once or twice a day at least 30 minutes before meals. Do not exceed recommended daily intake. Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

Warnings & Precautions

Storage: Store in a cool, dry place out of reach of children.

Do not exceed recommended daily intake. Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

Warning: Not advisable if pregnant, breastfeeding or if taking MAO inhibitor drugs.

Can cause drowsiness in sensitive individuals; do not drive or operate machinery if affected. Long term intakes of this amount of vitamin B6 may lead to mild tingling and numbness.

Formulation Notes

Positive Outlook with B vitamins & amino acids

Advanced formula Optimal benefit

Vegetarian and vegan

Vitamins B1, B3, B6 and B12 support normal function of the nervous system Vitamins B3, B5, B6, B12 and folate support normal psychological function and help reduce tiredness and fatigue Vitamin B6 helps regulate hormonal activity

Additional Information

NRV = Nutrient Reference Value

Storage: Store in a cool, dry place out of reach of children.

This product has not been tested on animals. Mind Health

Metadata

Product Details

UPC / SKU5 031013 104695
DSLD Entry Date2021-03-25
Product TypeOther Combinations
FormCapsule
BrandHigher Nature
DSLD ID245754
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
View all evidence for Thiamine →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.