Methyl Shield by NHC Natural Healthy Concepts — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

⚠️ Folate: 2000mg is 2000.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size

120 Servings

Other Combinations Product Type

80% Evidence Coverage

Supplement Facts — Evidence Check

Riboflavin

25 mg (1923% DV)

📊 19.2× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 25mg

Vitamin B6

10 mg (588% DV)

📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 10mg UL 100mg

Folate

2000 mcg DFE (500% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 2000.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 2000mg UL 1.0mg

Vitamin B12

1000 mcg (41667% DV)

📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 1.0mg

Betaine Anhydrous

500 mg

📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews

This product: 500mg

Other Ingredients

HPMC Stearic Acid Silica Microcrystalline Cellulose Magnesium Stearate Medium-Chain Triglyceride Oil

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (85% of products) Nutrient (48% of products) No Claim (1% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Take one capsule one to two times daily, or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Consult your healthcare practitioner prior to use.

Individuals taking medication should discuss potential interactions with their healthcare practitioner.

Do not use if tamper seal is damaged.

Storage: Keep closed in a cool, dry place out of reach of children.

🧪 Formulation Notes

Methyl Shield is a comprehensive formula designed to support optimal methylation and help maintain healthy homocysteine levels already within normal range.

It features five key nutrients that are involved in homocysteine metabolism: folate as calcium folinate and Quatrefolic for increased bioactivity; trimethylglycine; and vitamins B12, B6, and B2. These five nutrients, provided in activated forms, support enhanced methylation and overall cardiovascular health.

Does not contain: Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Optimal Methylation support formula

Gluten free Dairy free Soy free Nut free

Manufactured in a GMP compliant facility.

Additional Information

Professional use only

Storage: Keep closed in a cool, dry place out of reach of children.

Vegetarian Caps

This package is completely recyclable

Product Details

UPC / SKU 6 47732 92474 9

DSLD Entry Date 2020-07-23

Product Type Other Combinations

Form Capsule

Brand NHC Natural Healthy Concepts

DSLD ID 230789

Data Updated 2026-04-11

Research Evidence

22 Research Sources

49 Avg Quality Score

8 Rct

4 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Cochrane Review

1 Regulatory Source

B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis

Systematic Review BMJ open 2024

PubMed DOI

B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis

Meta Analysis Nutritional neuroscience 2022

PubMed DOI

B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries

Systematic Review The Cochrane database of systematic reviews 2010

PubMed DOI Cochrane

B Riboflavin supplements for blood pressure lowering in adults.

Cochrane Review The Cochrane database of systematic reviews

PubMed DOI Cochrane

B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis

Meta Analysis Nutrition reviews 2022

PubMed DOI

C Prophylaxis of migraine headaches with riboflavin: A systematic review

Systematic Review Journal of clinical pharmacy and therapeutics 2017

PubMed DOI

C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial

Rct Cephalalgia : an international journal of headache 2010

PubMed DOI

C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis

Meta Analysis International ophthalmology 2023

PubMed DOI

C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis

Meta Analysis The ocular surface 2014

PubMed DOI

C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial

Rct The journal of headache and pain 2015

PubMed DOI

View all evidence for Riboflavin →