Positive Outlook by Higher Nature — Ingredients, Evidence & Safety

🟢 97/100

This product looks safe

Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)
64% of ingredients have research evidence

C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 40mg is 1.1× the Tolerable Upper Intake Level (35mg)

Label Data

2 Capsule(s) Serving Size

Other Combinations Product Type

64% Evidence Coverage

Supplement Facts — Evidence Check

Thiamine

25 mg (2273% DV)

📊 20.8× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 25mg

Niacin

40 mg NE (250% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 1.1× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 40mg UL 35mg

Vitamin B6

20 mg (1429% DV)

📊 15.4× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 20mg UL 100mg

Folic Acid

100 mcg (50% DV)

✅ Within RDA (0.2× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 0.1mg UL 1.0mg

Vitamin B12

10 mcg (400% DV)

📊 4.2× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.01mg

Pantothenic Acid

90 mg (1500% DV)

📊 18.0× RDA — above typical dose 📚 1 studies — no high-quality reviews

RDA 5mg This product: 90mg

Tyrosine

430 mg

📊 Market median: 500.0mg (223 products) 📚 22 studies (Tier A: 0, B: 1)

This product: 430mg

Glutamine

500 mg

📊 Market median: 420.0mg (227 products)

Median 420.0mg This product: 500mg

5-HTP

90 mg

📊 Market median: 100.0mg (116 products) 📚 15 studies (Tier A: 0, B: 3)

This product: 90mg

Tri-Methyl Glycine

220 mg

Lemon Balm extract

18 mg

Other Ingredients

L-Glutamine L-Tyrosine Betaine Monohydrate Capsule Calcium D-Pantothenate L-5-Hydroxytryptophan Niacin Thiamine Hydrochloride Pyridoxine Hydrochloride Magnesium Stearate Lemon Balm extract Silicon Dioxide Folic Acid Methylcobalamin

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Children 4 or More Years of Age Vegan Vegetarian Adult (18 - 50 Years) Women (not pregnant or lactating) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Adults take 2 capsules once or twice a day, children over 6 years, 1 a day, on an empty stomach, or as your health professional advises. Do not exceed recommended daily intake.

⚠️ Warnings & Precautions

Do not exceed recommended daily intake. Food supplements should not be used as a substitute for a varied and balanced diet and healthy lifestyle.

Warning: Consult your doctor if under medical supervision or taking prescribed medications. Not advisable if pregnant or breast feeding, in cases of melanoma, schizophrenia, high blood pressure or if taking anti-depressant medication.

Can cause drowsiness in sensitive individuals; do not drive or operate machinery if affected. Long-term intakes of this amount of vitamin B6 may lead to mild tingling and numbness.

Storage: Store in a cool, dry, steam free environment out of reach of children.

🧪 Formulation Notes

Does not contain: Artificial colours, flavourings or preservatives, dairy products, gluten, lactose, salt, soya, wheat, yeast.

Suitable for vegetarians and vegans. This product is not tested on animals.

With B vits & amino acids

Vits B6, B12, thiamine & niacin support normal function of the nervous system. Vits B6, B12, niacin, folate & pantothenic acid support normal psychological function & help reduce tiredness & fatigue. Vitamin B6 helps regulate hormonal activity.

Additional Information

Ultimate nutrition

Storage: Store in a cool, dry, steam free environment out of reach of children.

Product Details

UPC / SKU 5 031013 104695

DSLD Entry Date 2020-05-22

Product Type Other Combinations

Form Capsule

Brand Higher Nature

DSLD ID 217119

Data Updated 2026-04-11

Research Evidence

100 Research Sources

56 Avg Quality Score

48 Systematic Review

30 Meta Analysis

13 Rct

6 Clinical Trial

1 Cochrane Review

1 Regulatory Source

B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol

Systematic Review The Cochrane database of systematic reviews 2013

PubMed DOI Cochrane

B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials

Systematic Review Nutritional neuroscience 2023

PubMed DOI

B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis

Meta Analysis BMJ open 2022

PubMed DOI

B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024

PubMed DOI

B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis

Systematic Review Intensive care medicine 2022

PubMed DOI

B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis

Meta Analysis Pain medicine (Malden, Mass.) 2020

PubMed DOI

B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis

Meta Analysis Critical care medicine 2021

PubMed DOI

B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Complementary therapies in medicine 2022

PubMed DOI

B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023

PubMed DOI

B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse

Systematic Review The Cochrane database of systematic reviews 2004

PubMed Cochrane

View all evidence for Thiamine →