Arthri-Flex Advantage + Vitamin D3

product on market Tablet or Pill 21st Century 🟢 Safety: 90/100
Brand: 21st Century
🟢 90/100

This product looks safe

  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 42% of ingredients have research evidence
A Label Compliance Grade

Product Label

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Safety Alerts

ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

2 Tablet(s) Serving Size
45 Servings
Other Combinations Product Type
42% Evidence Coverage

Supplement Facts — Evidence Check

Vitamin C
100 mg (110% DV)
50 mcg (250% DV)
📊 3.3× RDA — above typical dose (UL: 0.1 mg) 📚 604 studies (Tier A: 16, B: 251)
RDA 0.015mg This product: 0.05mg UL 0.1mg
200 mg (50% DV)
📊 Market median: 4002.0mg (1 products) 📚 20 studies (Tier A: 0, B: 2)
This product: 200mg
15 mg (140% DV)
✅ 1.4× RDA — within safe limits 📚 258 studies (Tier A: 6, B: 134)
RDA 11mg This product: 15mg UL 40mg
0.5 mg (60% DV)
✅ Within RDA (0.6× RDA of 0.9 mg) 📚 36 studies (Tier A: 0, B: 11)
RDA 0.9mg This product: 0.5mg UL 10mg
5 mg (220% DV)
✅ 2.2× RDA — within safe limits 📚 8 studies — no high-quality reviews
RDA 2.3mg This product: 5mg UL 11mg
220 mcg (490% DV)
📊 4.9× RDA — above typical dose (UL: 2 mg) 📚 2 studies — no high-quality reviews
RDA 0.045mg This product: 0.22mg UL 2mg
Potassium
195 mg (4% DV)
1500 mg
📊 Market median: 1000.0mg (1115 products) 📚 22 studies (Tier A: 0, B: 9)
This product: 1500mg
MSM
1500 mg
📊 Market median: 1000.0mg (2 products)
This product: 1500mg
80 mg
📊 Market median: 100.0mg (173 products)
Median 100.0mg This product: 80mg
Proprietary Blend
1045 mg

Other Ingredients

Cellulose Stearic Acid Contains Less Than 2% of

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (85% of products) Nutrient (70% of products) Approved Health (4% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: As a dietary supplement, adults take four (4) tablets daily, two (2) in the morning and two (2) in the afternoon, preferably with meals, or as directed by a healthcare provider. Do not exceed recommended dosage.

⚠️ Warnings & Precautions

Warning: If you are diabetic, consult your physician before using this product.

If you have a Shellfish allergy please consult your physician before using this product.

Warning: Consult a healthcare provider prior to use if pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur.

Keep out of reach of children.

Do not use if product appears to be tampered with or seal is broken.

Contains shellfish (shrimp, crab, lobster, crayfish).

🧪 Formulation Notes

Arthri-Flex Advantage + Vitamin D3 combines Glucosamine Sulfate & MSM (Methylsulfonylmethane) with our Proprietary Blend of premium Chicken Sternum Type II Collagen (naturally containing Chondroitin Sulfate), Hyaluronic Acid, herbal extracts, and mineral nutrients, that may work in synergy to support joints & cartilage. Now with Vitamin D3 for its bone support potential.

No added Yeast, Soy, Dairy, or Artificial Flavors.

Glucosamine, Chondroitin, MSM & Hyaluronic Acid Vitamin D3 for bone health 80 mg Hyaluronic Acid per serving

Gluten free Bovine free

Contains shellfish (shrimp, crab, lobster, crayfish).

Additional Information

Individual results may vary.

Store at room temperature.

Guaranteed quality Laboratory tested

Joint & cartilage support

Gluten free Bovine free

Lexibility support

Product Details

UPC / SKU 7 40985 27066 0
DSLD Entry Date 2019-09-24
Product Type Other Combinations
Form Tablet or Pill
Brand 21st Century
DSLD ID 207404
Data Updated 2026-04-11

Research Evidence

872 Research Sources
53 Avg Quality Score
309 Meta Analysis
309 Clinical Trial
111 Rct
71 Systematic Review
55 Guideline
4 Cochrane Review
4 Regulatory Source
2 Other
2 Narrative Review
2 Observational
1 Openfda Safety
A Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis
Meta Analysis The Cochrane database of systematic reviews 2009
PubMed DOI Cochrane
A Vitamin D supplementation for prevention of mortality in adults
Meta Analysis The Cochrane database of systematic reviews 2014
PubMed DOI Cochrane
A Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men
Meta Analysis The Cochrane database of systematic reviews 2014
PubMed DOI Cochrane
A Vitamin D supplementation for prevention of cancer in adults
Meta Analysis The Cochrane database of systematic reviews 2014
PubMed DOI Cochrane
A Interventions for preventing falls in older people in care facilities and hospitals
Meta Analysis The Cochrane database of systematic reviews 2018
PubMed DOI
A Drugs for preventing lung cancer in healthy people
Meta Analysis The Cochrane database of systematic reviews 2020
PubMed DOI
A Vitamin D supplementation for prevention of mortality in adults
Meta Analysis The Cochrane database of systematic reviews 2011
PubMed DOI Cochrane
A High prevalence of vitamin D deficiency in Asia: A systematic review and meta-analysis
Meta Analysis Critical reviews in food science and nutrition 2023
PubMed DOI
A The effect of vitamin D supplementation on depressive symptoms in adults: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2023
PubMed DOI
A Interventions for preventing falls in older people living in the community
Meta Analysis The Cochrane database of systematic reviews 2009
PubMed DOI
View all evidence for Vitamin D →

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