🟢 90/100

This product looks safe

  • Niacin: 108mg is 3.1× the Tolerable Upper Intake Level (35mg)
  • Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)
  • 88% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · methodology

This blend of B vitamins, including thiamine, riboflavin, and folate, supports cellular energy production and metabolic function. There is strong evidence supporting the role of these nutrients in maintaining neurological health and red blood cell formation. The profile maintains a high safety score for general supplementation.

AI-generated summary based on research evidence. Not medical advice.

Product Label

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Safety Alerts

⚠️ Niacin: 108mg is 3.1× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 667mg is 667.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size
60 Servings
Vitamin Product Type
88% Evidence Coverage

Supplement Facts — Evidence Check

100 mg (8333% DV)
📊 83.3× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)
RDA 1.2mg This product: 100mg
12.7 mg (977% DV)
📊 9.8× RDA — above typical dose 📚 13 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 12.7mg
108 mg (675% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 3.1× (UL: 35 mg) 📚 196 studies (Tier A: 5, B: 63)
RDA 14mg This product: 108mg UL 35mg
16.7 mg (982% DV)
📊 12.8× RDA — above typical dose (UL: 100 mg) 📚 114 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 16.7mg UL 100mg
667 mcg DFE (167% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 667.0× (UL: 1.0 mg) 📚 226 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 667mg UL 1.0mg
400 mcg (16667% DV)
📊 166.7× RDA — above typical dose 📚 139 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.4mg
400 mcg (1333% DV)
📊 13.3× RDA — above typical dose 📚 27 studies (Tier A: 0, B: 11)
RDA 0.03mg This product: 0.4mg
100 mg (2000% DV)
📊 20.0× RDA — above typical dose 📚 2 studies — no high-quality reviews
RDA 5mg This product: 100mg

Other Ingredients

Vegetarian Capsule Ascorbyl Palmitate

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Recommendations: As a dietary supplement, take 1 capsule, 1-2 times daily, with meals.

⚠️ Warnings & Precautions

Warning: If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

Keep out of the reach of children.

Use only if safety seal is intact.

🧪 Formulation Notes

Certified gluten-free by the gluten-free certification organization, www.gluten.org

With Metafolin L-5-MTHF; Broad-spectrum B vitamin support

Gluten-free, Non-GMO & Hypoallergenic

Additional Information

Store in a cool, dry place.

Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity.

Scan to learn about our hypoallergenic supplements

GF

Natural color variations can occur. Product can range from light yellow to bright yellow.

Product Details

UPC / SKU 7 66298 00024 4
DSLD Entry Date 2019-08-23
Product Type Vitamin
Form Capsule
DSLD ID 204418
Data Updated 2026-04-11

Research Evidence

100 Research Sources
56 Avg Quality Score
48 Systematic Review
30 Meta Analysis
13 Rct
6 Clinical Trial
1 Cochrane Review
1 Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004
View all evidence for Thiamine →

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DSLD ID: 204418 Fetched: 2026-04-11
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