Vitamin B Complex by up&up — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

⚠️ Niacin: 50mg is 1.4× the Tolerable Upper Intake Level (35mg)

Label Data

1 Tablet(s) Serving Size

Vitamin Product Type

88% Evidence Coverage

Supplement Facts — Evidence Check

Thiamine

50 mg (3333% DV)

📊 41.7× RDA — above typical dose 📚 76 studies (Tier A: 0, B: 33)

RDA 1.2mg This product: 50mg

Riboflavin

50 mg (2941% DV)

📊 38.5× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 50mg

Niacin

50 mg (250% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 1.4× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 50mg UL 35mg

Vitamin B6

50 mg (2500% DV)

📊 38.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 50mg UL 100mg

Folic Acid

400 mcg (100% DV)

✅ Within RDA (1.0× RDA of 0.4 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 0.4mg UL 1.0mg

Vitamin B12

50 mcg (833% DV)

📊 20.8× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 0.05mg

Biotin

50 mcg (17% DV)

✅ 1.7× RDA — within safe limits 📚 26 studies (Tier A: 0, B: 11)

RDA 0.03mg This product: 0.05mg

Pantothenic Acid

50 mg (500% DV)

📊 10.0× RDA — above typical dose 📚 1 studies — no high-quality reviews

RDA 5mg This product: 50mg

Other Ingredients

Dicalcium Phosphate Microcrystalline Cellulose Pyridoxine Hydrochloride Calcium Pantothenate Riboflavin Niacinamide Thiamine Mononitrate Croscarmellose Sodium Stearic Acid Silicon Dioxide Magnesium Stearate Dextrin Dextrose Lecithin Folic Acid Sodium Carboxymethylcellulose Sodium Citrate Cyanocobalamin Biotin

Label Claims — Verification

❓ All Other

❓ Approved Health

❓ Structure/Function

All Other (99% of products) Structure/Function (83% of products) Nutrient (47% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Suggested Use: Adults, take one tablet daily with the meal of your choice.

⚠️ Warnings & Precautions

If you are pregnant or nursing a baby, ask a doctor before using this product.

Keep out of reach of children.

🧪 Formulation Notes

CONTAINS: SOY

This product contains 100% of the US reference daily intake (RDI) of folate.

No artificial colors have been added to this formula, the product may vary in color.

GLUTEN FREE

Additional Information

ACTUAL SIZE

high potency helps support energy metabolism and nervous system health*

B

up&up(R)

ENERGY METABOLISM*

094 02 2114 : 4Y815 UW F2

ENERGY METABOLISM* Vitamin B complex consists of several essential nutrients needed by the body. This complex of B vitamins plays a role in well-being and energy metabolism and assists nerve function.*

Store at room temperature (59(0)-86(0)F).

This product is formulated per official U.S. Pharmacopeia (USP) standards to meet quality, potency and disintegration or dissolution requirements.

Adequate folate in healthful diets may reduce a woman's risk of having a child with a brain or spinal cord birth defect.

Each tablet in this bottle is clear coated for easy swallowing.

EXP11/13 2HN1695

ID482463

Product Details

UPC / SKU 0 70030 62498 9

DSLD Entry Date 2013-04-25

Product Type Vitamin

Form Tablet or Pill

Brand up&up

DSLD ID 20200

Data Updated 2026-04-11

Research Evidence

100 Research Sources

56 Avg Quality Score

48 Systematic Review

30 Meta Analysis

13 Rct

6 Clinical Trial

1 Cochrane Review

1 Regulatory Source

B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol

Systematic Review The Cochrane database of systematic reviews 2013

PubMed DOI Cochrane

B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials

Systematic Review Nutritional neuroscience 2023

PubMed DOI

B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis

Meta Analysis BMJ open 2022

PubMed DOI

B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024

PubMed DOI

B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis

Systematic Review Intensive care medicine 2022

PubMed DOI

B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis

Meta Analysis Pain medicine (Malden, Mass.) 2020

PubMed DOI

B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis

Meta Analysis Critical care medicine 2021

PubMed DOI

B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials

Meta Analysis Complementary therapies in medicine 2022

PubMed DOI

B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023

PubMed DOI

B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse

Systematic Review The Cochrane database of systematic reviews 2004

PubMed Cochrane

View all evidence for Thiamine →