Methyl Shield

product on market Capsule Natural Healthy Concepts 🟢 Safety: 92/100
Brand: Natural Healthy Concepts
🟢 92/100

This product looks safe

  • Folate: 2.0mg is 2.0× the Tolerable Upper Intake Level (1.0mg)
  • 80% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 2.0mg is 2.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size
60 Servings
Other Combinations Product Type
80% Evidence Coverage

Supplement Facts — Evidence Check

25 mg (147% DV)
📊 19.2× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 25mg
10 mg (500% DV)
📊 7.7× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 10mg UL 100mg
2000 mcg (500% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 2.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 2.0mg UL 1.0mg
1000 mcg (16667% DV)
📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 1.0mg
500 mg
📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews
This product: 500mg

Other Ingredients

HPMC Stearic Acid Silica Microcrystalline Cellulose Magnesium Stearate Medium-Chain Triglyceride Oil

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (85% of products) Nutrient (48% of products) No Claim (1% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Directions: Take one capsule one to two times daily, or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Professional use only

Consult your healthcare practitioner prior to use.

Individuals taking medication should discuss potential interactions with their healthcare practitioner.

Do not use if tamper seal is damaged.

Keep tightly closed in a cool, dry place out of reach of children.

🧪 Formulation Notes

It features the key nutrients that are involved in homocysteine metabolism: folate as calcium folate and quatrefolic for increased bioactivity; trimethylglycine; and vitamin B12, B6, and B2.

Does Not Contain: Wheat, gluten, corn, yeast, soy, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

Additional Information

Methyl Shield is a comprehensive formula designed to support optimal methylation and help maintain healthy homocysteine levels already within a normal range.

These 5 nutrients, provide in activated forms, support enhanced methylation and overall cardiovascular health.

Storage: Keep tightly closed in a cool, dry place out of reach of children.

Gluten free Dairy free Soy free Nut free

Optimal methylation support formula

Manufactured in a GMP compliant facility.

Vegetarian Caps

This package is completely recyclable

Rev. 031915 070724-01

Product Details

UPC / SKU 6 47732 92456 5
DSLD Entry Date 2018-08-31
Product Type Other Combinations
Form Capsule
Brand Natural Healthy Concepts
DSLD ID 179731
Data Updated 2026-04-11

Research Evidence

22 Research Sources
49 Avg Quality Score
8 Rct
4 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Cochrane Review
1 Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024
PubMed DOI
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022
PubMed DOI
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010
PubMed DOI Cochrane
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews
PubMed DOI Cochrane
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022
PubMed DOI
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017
PubMed DOI
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010
PubMed DOI
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023
PubMed DOI
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014
PubMed DOI
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015
PubMed DOI
View all evidence for Riboflavin →

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