🟢 95/100

This product looks safe

  • Folate: 250mg is 250.0× the Tolerable Upper Intake Level (1.0mg)
  • 88% of ingredients have research evidence
C Label Compliance Grade

Product Label

📸

Have a supplement label? Find it here.

Upload a photo of any supplement label to search our database of 92,312 products.

Safety Alerts

⚠️ Folate: 250mg is 250.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

2 Vegetarian Capsule(s) Serving Size
30 Servings
Other Combinations Product Type
88% Evidence Coverage

Supplement Facts — Evidence Check

50 mg (2941% DV)
📊 38.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 50mg UL 100mg
250 mcg DFE (63% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 250.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 250mg UL 1.0mg
500 mcg (20833% DV)
📊 208.3× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.5mg
50 mg (1000% DV)
📊 10.0× RDA — above typical dose 📚 1 studies — no high-quality reviews
RDA 5mg This product: 50mg
📊 Market median: 450.0mg (502 products) 📚 28 studies (Tier A: 0, B: 8)
This product: 250mg
📊 Market median: 260.0mg (249 products) 📚 156 studies (Tier A: 4, B: 61)
This product: 200mg
📊 Market median: 300.0mg (122 products) 📚 22 studies (Tier A: 0, B: 7)
This product: 100mg
100 mg
📊 Market median: 200.0mg (358 products) 📚 9 studies (Tier A: 0, B: 2)
This product: 100mg

Other Ingredients

Hydroxypropyl Methylcellulose L-Leucine Silica

Label Claims — Verification

All Other
Structure/Function
All Other (98% of products) Structure/Function (89% of products) Nutrient (43% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Doctor’s Suggested Use: Take 2 vegetarian capsules daily.

⚠️ Warnings & Precautions

Note: If you are pregnant or lactating, consult a health care professional before taking this product.

Keep out of reach of children.

🧪 Formulation Notes

Dairy free Soy free Gluten free

Vegetarian

Free-From Guarantee: Made without soy, gluten, dairy, wheat, eggs, shellfish, tree nuts, peanuts, fish, artificial sweeteners, artificial preservatives, artificial colors, and HFCS.

Additional Information

Unconditionally guaranteed for purity and labeled potency.

Store bottle with cap tightly closed in a cool, dry place.

This product contains botanical ingredients; therefore, variation in color may occur.

Dairy Free Soy Free Gluten Free Vegetarian

Targeted solutions For all-day healthy energy, mental focus, and stamina

SKU: DEV 02 C11000, 2017 R-1

Almost out? Call 1-866-599-9491 or visit healthydirections.com

Product Details

UPC / SKU 6 78829 20246 4
DSLD Entry Date 2018-06-25
Product Type Other Combinations
Form Capsule
DSLD ID 178455
Data Updated 2026-04-11

Research Evidence

153 Research Sources
55 Avg Quality Score
71 Systematic Review
51 Meta Analysis
19 Rct
6 Clinical Trial
2 Other
2 Regulatory Source
1 Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022
View all evidence for Vitamin B6 →

Compare Similar Products

View all Vitamin B6 products →