Methyl CpG by Ortho Molecular Products — Ingredients, Evidence & Safety

Product Label

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Safety Alerts

⚠️ Folate: 2.0mg is 2.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size

60 Servings

Other Combinations Product Type

80% Evidence Coverage

Supplement Facts — Evidence Check

Riboflavin

25 mg (1470% DV)

📊 19.2× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 25mg

Vitamin B6

50 mg (2500% DV)

📊 38.5× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)

RDA 1.3mg This product: 50mg UL 100mg

Folate

2000 mcg (500% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 2.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 2.0mg UL 1.0mg

Vitamin B12

1000 mcg (16667% DV)

📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)

RDA 0.0024mg This product: 1.0mg

Betaine

500 mg

📊 Market median: 496.0mg (192 products) 📚 20 studies — no high-quality reviews

This product: 500mg

Other Ingredients

natural Vegetable Capsules Microcrystalline Cellulose Magnesium Stearate Stearic Acid Calcium Silicate Silicon Dioxide

Label Claims — Verification

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (85% of products) Nutrient (48% of products) No Claim (1% of products)

Target Groups

Adult (18 - 50 Years)

Product Information

📋 Directions for Use

Suggested Use: 1 capsule per day or as recommended by your health care professional.

⚠️ Warnings & Precautions

If you are pregnant or nursing, consult your physician before taking this product.

As with all dietary supplements, some individuals may not tolerate or may be allergic to the ingredients used. Please read the ingredient panel carefully prior to ingestion. Cease taking this product and consult your physician if you have negative reactions upon ingestion.

Keep out of reach of children.

This product was sealed for your protection. Do not use if outer logoed neck seal or inner-seal is missing or damaged.

Do not accept if label shows signs of tampering

🧪 Formulation Notes

Formulated To Be Free Of Allergens Derived From: Gluten, corn, yeast, artificial colors and flavors.

Additional Information

Keep container tightly closed. Store at room temperature.

Product #145060 Label ID L-OMP100-145060-C V1

Vcaps

Learn more

Cardiovascular health

Professional Strength: Not for sale through Amazon.com

Product Details

UPC / SKU 6 15033 00145 2

DSLD Entry Date 2018-03-23

Product Type Other Combinations

Form Capsule

Brand Ortho Molecular Products

DSLD ID 174083

Data Updated 2026-04-11

Research Evidence

22 Research Sources

49 Avg Quality Score

8 Rct

4 Meta Analysis

4 Clinical Trial

3 Systematic Review

1 Cochrane Review

1 Regulatory Source

B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis

Systematic Review BMJ open 2024

PubMed DOI

B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis

Meta Analysis Nutritional neuroscience 2022

PubMed DOI

B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries

Systematic Review The Cochrane database of systematic reviews 2010

PubMed DOI Cochrane

B Riboflavin supplements for blood pressure lowering in adults.

Cochrane Review The Cochrane database of systematic reviews

PubMed DOI Cochrane

B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis

Meta Analysis Nutrition reviews 2022

PubMed DOI

C Prophylaxis of migraine headaches with riboflavin: A systematic review

Systematic Review Journal of clinical pharmacy and therapeutics 2017

PubMed DOI

C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial

Rct Cephalalgia : an international journal of headache 2010

PubMed DOI

C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis

Meta Analysis International ophthalmology 2023

PubMed DOI

C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis

Meta Analysis The ocular surface 2014

PubMed DOI

C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial

Rct The journal of headache and pain 2015

PubMed DOI

View all evidence for Riboflavin →