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Methyl CpG

product on market Capsule Ortho Molecular Products Safety: 92/100
92/100

This product looks safe

  • Folate: 2.0mg is 2.0× the Tolerable Upper Intake Level (1.0mg)
  • 80% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This profile contains B vitamins and betaine, which are supported by strong evidence for their roles in homocysteine metabolism and methylation. These ingredients facilitate the conversion of homocysteine to methionine. However, overall evidence coverage for this specific formulation is limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 2.0mg is 2.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Methyl CpG
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
60
Servings
Other Combinations
Product Type
80%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

25 mg (1470% DV)
19.2× RDA — above typical dose 13 studies (A:0, B:1)
50 mg (2500% DV)
38.5× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
2000 mcg (500% DV)
Exceeds UL by 2.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
1000 mcg (16667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)
500 mg
Market median: 496.0mg (192 products) 20 studies — no high-quality reviews

Other Ingredients

natural Vegetable Capsules Microcrystalline Cellulose Magnesium Stearate Stearic Acid Calcium Silicate Silicon Dioxide
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested Use: 1 capsule per day or as recommended by your health care professional.

Warnings & Precautions

If you are pregnant or nursing, consult your physician before taking this product.

As with all dietary supplements, some individuals may not tolerate or may be allergic to the ingredients used. Please read the ingredient panel carefully prior to ingestion. Cease taking this product and consult your physician if you have negative reactions upon ingestion.

Keep out of reach of children.

This product was sealed for your protection. Do not use if outer logoed neck seal or inner-seal is missing or damaged.

Do not accept if label shows signs of tampering

Formulation Notes

Formulated To Be Free Of Allergens Derived From: Gluten, corn, yeast, artificial colors and flavors.

Additional Information

Keep container tightly closed. Store at room temperature.

Product #145060 Label ID L-OMP100-145060-C V1

Vcaps

Learn more

Cardiovascular health

Professional Strength: Not for sale through Amazon.com

Metadata

Product Details

UPC / SKU6 15033 00145 2
DSLD Entry Date2018-03-23
Product TypeOther Combinations
FormCapsule
BrandOrtho Molecular Products
DSLD ID174083
Data Updated2026-04-11
Research

Research Evidence

22
Research Sources
49
Avg Quality
8
Rct
4
Meta Analysis
4
Clinical Trial
3
Systematic Review
1
Cochrane Review
1
Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024 PubMed DOI
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022 PubMed DOI
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010 PubMed DOI
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews PubMed DOI
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022 PubMed DOI
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017 PubMed DOI
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010 PubMed DOI
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023 PubMed DOI
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014 PubMed DOI
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015 PubMed DOI
View all evidence for Riboflavin →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.