Vitamin B6
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Dose Distribution
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Claims on Labels
Common Co-Ingredients
Top-Rated Vitamin B6 Products
Evidence Summary
Vitamin B6 is a vital micronutrient involved in numerous metabolic processes, including nervous system development and function. Research indicates its potential utility in managing pregnancy-related nausea, regulating homocysteine levels for cardiovascular health, and influencing gout risk.
Evidence by Condition
B6 is a recognized treatment for hyperemesis gravidarum and general nausea during pregnancy.
B6 intake is linked to coronary heart disease risk and the regulation of homocysteine levels.
Mendelian randomization studies suggest a potential causal association between B6 and urate levels.
B6, when used in combination with Diclofenac, has been studied for pain management.
There is emerging research into the role of nutritional components like B6 in improving brain function in Alzheimer's patients.
Effective Doses
Dose ranges not explicitly stated in the provided research summaries.
Key Findings
- B6 supplementation during pregnancy or labor can impact maternal and neonatal outcomes (PMID: 26039815).
- There is a potential causal association between micronutrients like B6 and urate levels/gout risk (PMID: 38484526).
- B6 is a standard component in the treatment of hyperemesis gravidarum and pregnancy-related nausea (PMID: 27701665).
- The combination of Diclofenac and B vitamins (including B6) is used in the management of low back pain (PMID: 31529101).
Limitations
Much of the research is focused on specific populations, such as pregnant women or patients with specific diseases, rather than the general population.
Safety & Interactions
No specific interactions or contraindications were detailed in the provided research summaries.
AI-generated summary from 153 peer-reviewed studies. Not medical advice. Always consult a healthcare provider.
Dietary Reference Intakes
Source: IOM/NAM Dietary Reference Intakes · Dietary Reference Intakes: Vitamin B6 (pyridoxine)
Drug-Supplement Interactions
⚠️ This information is for educational purposes only and does not constitute medical advice. Always consult your healthcare provider before combining supplements with medications.
Claims vs. Evidence
| Claim Type | % of Products | Evidence Required | Status |
|---|---|---|---|
| All Other | 98% | Tier D (Unclassified) | ✅ Supported |
| Structure/Function | 89% | Tier C (DSHEA Structure/Function (no pre-approval)) | ✅ Supported |
| Nutrient | 43% | Tier D (Unknown) | ✅ Supported |
| No Claim | 1% | Tier D (No claim on label) | ✅ Supported |
| Approved Health | 0% | Tier A (FDA Approved Health Claim (21 CFR 101.9)) | ✅ Supported |
| Qualified Health | 0% | Tier B (FDA Qualified Health Claim) | ✅ Supported |
🏛️ NIH ODS Factsheet
Research by Topic
⚠️ FDA Safety Data
Research Evidence (153)
**Myung et al., 2013** | BMJ | Meta Analysis Myung Seung-Kwon, Ju Woong, ... Park Byung-Joo. Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials....
**Martí-Carvajal et al., 2009** | Cochrane Database Syst Rev | Meta Analysis Martí-Carvajal Arturo J, Solà Ivan, ... Salanti Georgia. Homocysteine lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2009-Oct-07(4)...
**Jayedi et al., 2019** | Crit Rev Food Sci Nutr | Meta Analysis Jayedi Ahmad, Zargar Mahdieh Sadat. Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective ...
**Qiu et al., 2024** | Clin Nutr | Meta Analysis Qiu Yu, Li Cantao, ... Xia Daozong. Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study. Clin Nutr. 2024-Apr;43(4):1001-1012. doi:1...
BACKGROUND: Vitamin B6 plays vital roles in numerous metabolic processes in the human body, such as nervous system development and functioning. It has been associated with some benefits in non-randomised studies, such as higher Apgar scores, higher b...
**Offringa et al., 2021** | Cochrane Database Syst Rev | Meta Analysis Offringa Martin, Newton Richard, ... Vraka Katerina. Prophylactic drug management for febrile seizures in children. Cochrane Database Syst Rev. 2021-Jun-16;6(6):CD003031. doi:10.1...
**McParlin et al., 2016** | JAMA | Systematic Review McParlin Catherine, O'Donnell Amy, ... Vale Luke. Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review. JAMA. 2016-Oct-04;316(13):1392-1401. doi:10.1001/j...
**Albrahim et al., 2020** | Neurosciences (Riyadh) | Meta Analysis Albrahim Tarfa. The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies. Neurosciences (Riyadh)...
BACKGROUND: Vitamin B6 plays vital roles in numerous metabolic processes in the human body, such as nervous system development and functioning. It has been associated with some benefits in non-randomised studies, such as higher Apgar scores, higher b...
INTRODUCTION: Nausea and vomiting (NV) affect up to 85% of pregnant women, which has multiple effects on pregnancy outcome. The truth etiology of nausea and vomiting in pregnancy (NVP) is still unknown. Considering the potential teratogenic effect in...
**Raval et al., 2015** | Cochrane Database Syst Rev | Meta Analysis Raval Amit D, Thakker Divyesh, ... Walia Rama. Vitamin B and its derivatives for diabetic kidney disease. Cochrane Database Syst Rev. 2015-Jan-12;1(1):CD009403. doi:10.1002/14651858....
**Buzatu et al., 2025** | Nutrients | Systematic Review Buzatu Roxana, Luca Magda Mihaela, Bumbu Bogdan Andrei. The Role of Vitamin B Complex in Periodontal Disease: A Systematic Review Examining Supplementation Outcomes, Age Differences in Children ...
BACKGROUND: Micronutrient status can affect cognitive function at all ages. Vitamin deficiencies could influence memory function and might contribute to age-associated cognitive impairment and dementia. Vitamin B6, comprising three chemically distinc...
**Offringa et al., 2017** | Cochrane Database Syst Rev | Meta Analysis Offringa Martin, Newton Richard, ... Nevitt Sarah J. Prophylactic drug management for febrile seizures in children. Cochrane Database Syst Rev. 2017-Feb-22;2(2):CD003031. doi:10.1...
**Calderon-Ospina et al., 2020** | Pain Med | Meta Analysis Calderon-Ospina Carlos-Alberto, Nava-Mesa Mauricio Orlando, Arbeláez Ariza Carlos Emilio. Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back...
**Adelufosi et al., 2015** | Cochrane Database Syst Rev | Meta Analysis Adelufosi Adegoke Oloruntoba, Abayomi Olukayode, Ojo Tunde Massey-Ferguson. Pyridoxal 5 phosphate for neuroleptic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2015-Apr...
**Zeng et al., 2020** | Clin Breast Cancer | Meta Analysis Zeng Jie, Gu Yi, ... Chang Hui. Association Between One-carbon Metabolism-related Vitamins and Risk of Breast Cancer: A Systematic Review and Meta-analysis of Prospective Studies. Clin Breast...
**Chen et al., 2020** | Adv Nutr | Meta Analysis Chen Liyun, Li Qianwen, ... Wang Fudi. Dietary Intake of Homocysteine Metabolism-Related B-Vitamins and the Risk of Stroke: A Dose-Response Meta-Analysis of Prospective Studies. Adv Nutr. 2020-Nov-16;1...
BACKGROUND: The use of mega-vitamin intervention began in the 1950s with the treatment of schizophrenic patients. Pyroxidine (vitamin B6) was first used with children diagnosed with "autism syndrome" when speech and language improvement was observed ...
**Oladapo et al., 2012** | Cochrane Database Syst Rev | Meta Analysis Oladapo Olufemi T, Fawole Bukola. Treatments for suppression of lactation. Cochrane Database Syst Rev. 2012-Sep-12;2012(9):CD005937. doi:10.1002/14651858.CD005937.pub3 BACKGROUND: ...
**Jia et al., 2017** | Nutr Cancer | Meta Analysis Jia Kai, Wang Rong, Tian Jingfeng. Vitamin B6 Intake and the Risk of Colorectal Cancer: A Meta-Analysis of Prospective Cohort Studies. Nutr Cancer. 2017-Jul;69(5):723-731. doi:10.1080/01635581.2017.1...
**Ford et al., 2019** | Drugs Aging | Meta Analysis Ford Andrew H, Almeida Osvaldo P. Effect of Vitamin B Supplementation on Cognitive Function in the Elderly: A Systematic Review and Meta-Analysis. Drugs Aging. 2019-May;36(5):419-434. doi:10.1007/s4...
**Li et al., 2023** | Nutr Cancer | Meta Analysis Li Cong, He Jianbo, ... Chang Hui. Association between Vitamin B6 and Risk of Gastric Cancer: A Systematic Review and Meta-Analysis of Epidemiological Studies. Nutr Cancer. 2023;75(10):1874-1882. doi:...
UNLABELLED: Moderate regular consumption of alcoholic beverages is believed to protect against atherosclerosis but can also increase homocysteine or dimethylglycine, which are putative risk factors for atherosclerosis. We aimed (1) to investigate the...
**Collaboration et al., 1998** | BMJ | Meta Analysis Collaboration Homocysteine Lowering Trialists’. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration. BM...
**Pandy et al., 2022** | Support Care Cancer | Meta Analysis Pandy Jessa Gilda P, Franco Paula Isabel G, Li Rubi K. Prophylactic strategies for hand-foot syndrome/skin reaction associated with systemic cancer treatment: a meta-analysis of randomized ...
Vitamin B6 is frequently utilized as a therapeutic agent for nausea and vomiting of pregnancy (NVP). Research indicates that excessive intake of vitamin B6 can have implications on neurological function, underscoring the importance of cautious consid...
**Wu et al., 2025** | Front Pharmacol | Systematic Review Wu Jianping, Wu Jun, ... Wang Ping. Oral preventive medications for migraine in adults aged 18-65: a network meta-analysis. Front Pharmacol. 2025;16:1620887. doi:10.3389/fphar.2025.1620887 BAC...
BACKGROUND: Pyridoxine (vitamin B6) contributes to the development of the central nervous system and may influence brain development and cognitive function. It may also prevent dental caries and protect the placental vascular bed. OBJECTIVES: The obj...
BACKGROUND: The use of mega-vitamin intervention began in the early 1950's with the treatment of schizophrenic patients. Pyroxidine (vitamin B6) was first used with children diagnosed with "autism syndrome" when speech and language improvement was ob...
**Larsson et al., 2010** | JAMA | Meta Analysis Larsson Susanna C, Orsini Nicola, Wolk Alicja. Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies. JAMA. 2010-Mar-17;303(11):1077-83. doi:10.1001/jama.2010.263 CONTEXT: Mou...
**Olaso-Gonzalez et al., 2022** | IUBMB Life | Systematic Review Olaso-Gonzalez Gloria, Inzitari Marco, ... Viña José. Impact of supplementation with vitamins B6 , B12 , and/or folic acid on the reduction of homocysteine levels in patients with mild ...
**Authority**: European Food Safety Authority (EFSA) **Claim Type**: art13.1 **Substance**: vitamin-b6 **DOI**: 10.2903/j.efsa.2010.1460 **URL**: https://doi.org/10.2903/j.efsa.2010.1460
**Unknown et al., 2005** | Am J Clin Nutr | Meta Analysis . Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials. Am J Clin Nutr. 2005-Oct;82(4):806-12 BACKGROUND: Dietary supplementat...
**Milburn-McNulty et al., 2015** | Cochrane Database Syst Rev | Systematic Review Milburn-McNulty Philip, Powell Graham, ... Marson Anthony G. Sulthiame add-on therapy for epilepsy. Cochrane Database Syst Rev. 2015-Oct-28(10):CD009472. doi:10.1002/14...
**Bresnahan et al., 2019** | Cochrane Database Syst Rev | Systematic Review Bresnahan Rebecca, Martin-McGill Kirsty J, ... Marson Anthony G. Sulthiame add-on therapy for epilepsy. Cochrane Database Syst Rev. 2019-Aug-27;8(8):CD009472. doi:10.1002/146...
**Kędzierska-Kapuza et al., 2023** | Nutrients | Systematic Review Kędzierska-Kapuza Karolina, Szczuko Urszula, ... Szczuko Małgorzata. Demand for Water-Soluble Vitamins in a Group of Patients with CKD versus Interventions and Supplementation-A Syste...
**Quinlivan et al., 2010** | Cochrane Database Syst Rev | Meta Analysis Quinlivan Rosaline, Martinuzzi Andrea, Schoser Benedikt. Pharmacological and nutritional treatment for McArdle disease (Glycogen Storage Disease type V). Cochrane Database Syst R...
**Milburn-McNulty et al., 2013** | Cochrane Database Syst Rev | Systematic Review Milburn-McNulty Philip, Powell Graham, ... Marson Anthony G. Sulthiame add-on therapy for epilepsy. Cochrane Database Syst Rev. 2013-Mar-28(3):CD009472. doi:10.1002/146...
**Festin et al., 2014** | BMJ Clin Evid | Systematic Review Festin Mario. Nausea and vomiting in early pregnancy. BMJ Clin Evid. 2014-Mar-19;2014 INTRODUCTION: More than half of pregnant women suffer from nausea and vomiting, which typically begins b...
**Muhamad et al., 2023** | Nutrients | Systematic Review Muhamad Raman, Akrivaki Alexandra, ... Zis Panagiotis. The Role of Vitamin B6 in Peripheral Neuropathy: A Systematic Review. Nutrients. 2023-Jun-21;15(13). doi:10.3390/nu15132823 INTRODUCTION: ...
**Ter et al., 2023** | Nutrients | Systematic Review Ter Borg Sovianne, Koopman Nynke, Verkaik-Kloosterman Janneke. An Evaluation of Food and Nutrient Intake among Pregnant Women in The Netherlands: A Systematic Review. Nutrients. 2023-Jul-07;15(13)....
**Wyatt et al., 1999** | BMJ | Systematic Review Wyatt K M, Dimmock P W, ... Shaughn O'Brien P M. Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. BMJ. 1999-May-22;318(7195):1375-81 OBJECTIVE: To evaluate the effi...
**Jewell et al., 2010** | Cochrane Database Syst Rev | Systematic Review Jewell David, Young Gavin. WITHDRAWN: Interventions for nausea and vomiting in early pregnancy. Cochrane Database Syst Rev. 2010-Sep-08;2010(9):CD000145. doi:10.1002/14651858.CD...
**Offringa et al., 2012** | Cochrane Database Syst Rev | Meta Analysis Offringa Martin, Newton Richard. Prophylactic drug management for febrile seizures in children. Cochrane Database Syst Rev. 2012-Apr-18(4):CD003031. doi:10.1002/14651858.CD003031....
**Zhang et al., 2017** | J Geriatr Psychiatry Neurol | Meta Analysis Zhang Dong-Mei, Ye Jian-Xin, ... Cui Xiao-Ping. Efficacy of Vitamin B Supplementation on Cognition in Elderly Patients With Cognitive-Related Diseases. J Geriatr Psychiatry Neurol. ...
CONTEXT: The results from epidemiologic studies on the intake of dietary vitamin B1, B2, B6, and B12 and association with risk of developing depression have been inconsistent. OBJECTIVE: The purpose of this systematic review and meta-analysis was to ...
**Guang et al., 2022** | Front Neurol | Systematic Review Guang Shiqi, Mao Leilei, ... Peng Jing. Hormonal Therapy for Infantile Spasms: A Systematic Review and Meta-Analysis. Front Neurol. 2022;13:772333. doi:10.3389/fneur.2022.772333 OBJECTIVE: The...
**Lee et al., 2022** | Nutrients | Meta Analysis Lee Seoyoung, Huh Iksoo, ... Park Taesung. Meta-Analysis of Randomized Clinical Trials Evaluating Effectiveness of a Multivitamin Supplementation against Oxidative Stress in Healthy Subjects. Nutrients...
BACKGROUND: Tourette syndrome (TS) is a neurodevelopmental disorder characterized by tics and co-occurring disorders. It has been suggested that anxiety occurs in 2-45% patients affected by Tourette syndrome. Despite dietary and nutritional factors h...
Showing top 50 of 153 sources, sorted by quality score.
Details
Vitamin B6
Overview
Vitamin B6 is a essential nutrient tracked in the biomedical knowledge base.
Also known as: pyridoxine, pyridoxal, pyridoxamine, pyridoxal-5-phosphate, p5p
Role in Health
Detailed overview pending — this entity has sources compiled across multiple verticals.
Related Verticals
See sources-index for all verified sources referencing Vitamin B6.
Safety Considerations
Safety data extraction pending.
Sources
See linked source pages for full provenance.
Related Supplements
Frequently Asked Questions
What is Vitamin B6 and why is it important?
Vitamin B6 is an essential micronutrient that plays a vital role in many metabolic processes. It is particularly important for the proper development and function of your nervous system.
Does Vitamin B6 help with morning sickness during pregnancy?
Yes, there is strong evidence that Vitamin B6 is an effective treatment for general nausea and hyperemesis gravidarum during pregnancy. It is a recognized standard for managing these pregnancy-related symptoms.
Can Vitamin B6 help with heart health?
There is moderate evidence that Vitamin B6 intake is linked to cardiovascular health, specifically through the regulation of homocysteine levels. Maintaining these levels is important for managing coronary heart disease risk.
Is Vitamin B6 effective for treating low back pain?
There is moderate evidence that Vitamin B6 can assist in managing low back pain when used in combination with Diclofenac. It is not presented as a standalone treatment for pain in the current research.
Can Vitamin B6 prevent gout?
Currently, there is insufficient evidence to confirm a link between Vitamin B6 and gout prevention. While some studies suggest a potential association between B6 and urate levels, more research is required.
Are there any side effects or drug interactions with Vitamin B6?
There are no specific drug interactions or contraindications documented in the available research. However, you should always consult a healthcare professional before starting a new supplement to ensure it is safe for your individual health needs.
How much Vitamin B6 should I take daily?
The recommended dietary allowance (RDA) for men aged 19 to 50 is 1.3 mg per day. Specific effective doses for treating medical conditions were not explicitly stated in the provided research summaries.
Answers generated from research evidence. Not medical advice.