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Vitamin B6 × Anticonvulsants

MODERATE INTERACTION

⚠️ Mechanism

Interaction identified from DDInter 2.0 database. Specific drugs: Phenytoin

📋 Effect

See mechanism description

💊 Management

Consult healthcare provider before combining.

Plain Language Summary

This combination is considered moderately risky. Taking Vitamin B6 with certain anticonvulsants, such as phenytoin, may change how the medication works in your body.

Source

DDInter 2.0 (ddinter.scbdd.com)

Supporting Research

Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials PMID:23335472 DOI:10.1136/bmj.f10 2013
Homocysteine lowering interventions for preventing cardiovascular events PMID:19821378 DOI:10.1002/14651858.CD006612.pub2 2009
Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study PMID:38484526 DOI:10.1016/j.clnu.2024.03.003 2024
Prophylactic drug management for febrile seizures in children PMID:34131913 DOI:10.1002/14651858.CD003031.pub4 2021
Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review PMID:27701665 DOI:10.1001/jama.2016.14337 2016
The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies PMID:31982903 DOI:10.17712/nsj.2020.1.20190037 2020
The Role of Vitamin B Complex in Periodontal Disease: A Systematic Review Examining Supplementation Outcomes, Age Differences in Children and Adults, and Aesthetic Changes PMID:40218924 DOI:10.3390/nu17071166 2025
Prophylactic drug management for febrile seizures in children PMID:28225210 DOI:10.1002/14651858.CD003031.pub3 2017
Medical Disclaimer: This interaction record is for informational and educational purposes only and does not constitute medical advice. Drug-supplement interactions can be dangerous. Always consult your healthcare provider or pharmacist before combining any supplement with prescription medications. Do not stop or change any medication without professional guidance.