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Eye Defense

product on market Tablet or Pill Nature Made Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 57% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula combines vitamins A, C, E, and zinc with copper to support ocular health. There is strong evidence that these antioxidants help protect the eyes from oxidative stress and age-related decline. However, the overall evidence coverage for this specific ingredient profile remains limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for Eye Defense
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Tablet(s)
Serving Size
25
Servings
Other Combinations
Product Type
57%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Vitamin A
5000 IU (100% DV)
Vitamin C
350 mg (583% DV)
100 IU (333% DV)
4.5× RDA — above typical dose (UL: 1000 mg) 179 studies (A:3, B:90)
15 mg (100% DV)
1.4× RDA — within safe limits 263 studies (A:6, B:134)
0.4 mg (20% DV)
Within RDA (0.4× RDA) 37 studies (A:0, B:11)
5 mg
Market median: 10.0mg (105 products) 2 studies (A:0, B:1)
1 mg
Market median: 4.0mg (32 products)

Other Ingredients

Cellulose Gel Ascorbic Acid DL-Alpha-Tocopheryl Acetate Gelatin Talc Corn Starch Hydroxypropyl Methylcellulose Croscarmellose Sodium Zinc Oxide Titanium Dioxide modified Food Starch Lutein Silica Gel Magnesium Stearate Polyethylene Glycol Beta-Carotene Triethyl Citrate Polysorbate 80 Sodium Citrate Zeaxanthin Copper Oxide Ingredients
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

SUGGESTED USE: Take two tablets daily with food. Tablets can be taken together or at different times during the day.

Warnings & Precautions

Store in a cool, dry place, out of reach of children.

Do not use if imprinted seal under cap is broken or missing.

Formulation Notes

No Artificial Colors - No Artificial Flavors - No Preservatives - No Chemical Solvents, Yeast or Gluten

Additional Information

List No. 1249 L22AA Cat. A344 5A004

Recommended By Pharmacists

For Healthy Vision NATURE'S OPTIMAL RATIO Lutein 5 to 1 RATIO Zeaxanthin High Potency Antioxidant Formula

USP has tested and verified ingredients, potency and manufacturing process. USP sets official standards for dietary supplements. www.uspverified.org Lot.: Exp.:

Eye Defense - High potency antioxidant formula provides key nutrients to fight against the effects of aging on eye health.

Keep bottle tightly closed.

DIETARY SUPPLEMENT USP VERIFIED(TM)

Vitamins A, C, E and Zinc.

Metadata

Product Details

DSLD Entry Date2012-06-01
Product TypeOther Combinations
FormTablet or Pill
BrandNature Made
DSLD ID8821
Data Updated2026-04-11
Research

Research Evidence

337
Research Sources
54
Avg Quality
161
Meta Analysis
68
Systematic Review
51
Rct
48
Clinical Trial
2
Other
2
Regulatory Source
1
Narrative Review
1
Cochrane Review
1
Guideline
1
Openfda Safety
A Vitamin A supplementation for preventing morbidity and mortality in children from six months to five years of age
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants six months of age or less
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplementation for reducing the risk of mother-to-child transmission of HIV infection
Meta Analysis The Cochrane database of systematic reviews 2011 PubMed DOI
A Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis
Meta Analysis BMJ (Clinical research ed.) 2011 PubMed DOI
A Fortification of staple foods with vitamin A for vitamin A deficiency
Systematic Review The Cochrane database of systematic reviews 2019 PubMed DOI
A Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age
Narrative Review The Cochrane database of systematic reviews 2016 PubMed DOI
A Vitamin A and fish oils for preventing the progression of retinitis pigmentosa
Meta Analysis The Cochrane database of systematic reviews 2020 PubMed DOI
A Exercise training-induced changes in exerkine concentrations may be relevant to the metabolic control of type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Journal of sport and health science 2023 PubMed DOI
A Food fortification with multiple micronutrients: impact on health outcomes in general population
Meta Analysis The Cochrane database of systematic reviews 2019 PubMed DOI
A Oral vitamin A supplements to prevent acute upper respiratory tract infections in children up to seven years of age
Meta Analysis The Cochrane database of systematic reviews 2024 PubMed DOI
View all evidence for Vitamin A →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.