Home/ Supplements/ Vitamin B6/ Sublingual B-12 2500 mcg

Sublingual B-12 2500 mcg

product on market Other (e.g. tea bag) Puritan's Pride Safety: 82/100
82/100

This product is generally safe

  • Folate: 1333mg is 1333.0× the Tolerable Upper Intake Level (1.0mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 80% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

Vitamin B12, folate, and B6 are supported by strong evidence for maintaining nerve function and red blood cell production. Biotin and the proprietary energy blend have more limited evidence regarding metabolic support. The overall evidence coverage for this specific formulation is low at 0.8%.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Folate: 1333mg is 1333.0× the Tolerable Upper Intake Level (1.0mg)

Contains proprietary blend — exact ingredient amounts not disclosed

Label

Product Label

Label for Sublingual B-12 2500 mcg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Microlozenge(s)
Serving Size
Other Combinations
Product Type
80%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

6 mg (353% DV)
4.6× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
1333 mcg DFE (333% DV)
Exceeds UL by 1333.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
2500 mcg (104167% DV)
1041.7× RDA — above typical dose 139 studies (A:1, B:44)
100 mcg (333% DV)
3.3× RDA — above typical dose 27 studies (A:0, B:11)
Proprietary Energy Blend (Combination)
2.75 mg

Other Ingredients

Mannitol Crospovidone Stearic Acid Vegetable Cellulose Natural and Artificial flavor Contains Less Than 2% of
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Info

Product Information

Directions for Use

Directions: For adults, take one (1) microlozenge daily, preferably with a meal. Place microlozenge under tongue for 30 seconds before swallowing.

Warnings & Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Formulation Notes

No artificial color, no sugar, no milk, no lactose, no gluten, no yeast, no fish. Sodium free.

With folate, B-6, biotin

Additional Information

Store at room temperature.

To reorder item # 18641 www.puritan.com 1-800-645-1030

Item # 18641 B18640 04C

QA Quality Assured

Fast acting

B

Metadata

Product Details

UPC / SKU0 25077 18641 9
DSLD Entry Date2017-08-22
Product TypeOther Combinations
FormOther (e.g. tea bag)
BrandPuritan's Pride
DSLD ID76628
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.