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SAM-e 400 mg

product on market Tablet or Pill HBC Protocols Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 75% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

S-Adenosyl-Methionine is supported by moderate evidence for managing depressive symptoms and joint health. Vitamin B6, B12, and folic acid serve as essential cofactors for neurotransmitter synthesis and methylation processes. Research generally supports these ingredients for cognitive and mood support, though evidence coverage for this specific blend is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAM-e 400 mg
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Tablet(s)
Serving Size
Other Combinations
Product Type
75%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 500.0mg (193 products) 7 studies — no high-quality reviews
2 mg
1.5× RDA — within safe limits 114 studies (A:3, B:35)
50 mcg
20.8× RDA — above typical dose 139 studies (A:1, B:44)
200 mcg
Within RDA (0.5× RDA) 226 studies (A:10, B:105)

Other Ingredients

S-Adensoyl Methionine Microcrystalline Cellulose Magnesium Stearate Talc Metocrylic Copolymer
Claims

Label Claims — Verification

Unverified Structure/Function
Info

Product Information

Directions for Use

Directions For Use: Adults take 1 - 4 tablets daily or as directed by your physician.

Formulation Notes

S-adenosyl-Methionine Disulfate Tosylate

Additional Information

SAMe is a naturally derived product which helps support positive mood balance. It has been shown to support glutathione production which helps support the body's antioxidant system and healthy liver function, as well as mitigate dangerous levels of homocysteine.

Metadata

Product Details

DSLD Entry Date2017-06-23
Product TypeOther Combinations
FormTablet or Pill
BrandHBC Protocols
DSLD ID74981
Data Updated2026-04-11
Research

Research Evidence

14
Research Sources
50
Avg Quality
8
Rct
4
Meta Analysis
2
Clinical Trial
B The Effect of Fenugreek in Type 2 Diabetes and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis International journal of molecular sciences 2023 PubMed DOI
B A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes
Rct African health sciences 2019 PubMed DOI
C The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial
Rct Complementary therapies in medicine 2020 PubMed DOI
C Effect of saffron and fenugreek on lowering blood glucose: A systematic review with meta-analysis
Meta Analysis Phytotherapy research : PTR 2023 PubMed DOI
C Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis
Meta Analysis Journal of ethnopharmacology 2016 PubMed DOI
C Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials
Meta Analysis Phytotherapy research : PTR 2020 PubMed DOI
C Investigating the Effectiveness of Fenugreek on the Quantity of Breast Milk and the Level of Prolactin in Mothers of Preterm Newborns: A Randomized Controlled Clinical Trial
Rct Current drug research reviews 2025 PubMed DOI
C Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus
Rct Chinese journal of integrative medicine 2008 PubMed
C Impact of Fenugreek Supplementation on Obesity and Hyperglycemia Among Diabetic Adults in Saudi Arabia
Clinical Trial ClinicalTrials.gov 2025
C Fenugreek bread: a treatment for diabetes mellitus
Rct Journal of medicinal food 2009 PubMed DOI
View all evidence for Fenugreek →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.