SAM-e 400 mg
100/100
This product looks safe
- No ingredients exceed tolerable upper intake levels
- 75% of ingredients have research evidence
A
Label Compliance Grade
Product Label
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Label Data
1 Tablet(s)
Serving Size
Other Combinations
Product Type
75%
Evidence Coverage
Supplement Facts — Evidence Check
📊 Market median: 500.0mg (193 products)
📚 7 studies — no high-quality reviews
2 mg
✅ 1.5× RDA — within safe limits
📚 113 studies (Tier A: 3, B: 35)
50 mcg
📊 20.8× RDA — above typical dose
📚 138 studies (Tier A: 1, B: 44)
200 mcg
✅ Within RDA (0.5× RDA of 0.4 mg)
📚 225 studies (Tier A: 10, B: 105)
Other Ingredients
S-Adensoyl Methionine
Microcrystalline Cellulose
Magnesium Stearate
Talc
Metocrylic Copolymer
Label Claims — Verification
❓
Structure/Function
All Other (99% of products)
Structure/Function (79% of products)
Nutrient (9% of products)
Target Groups
Adult (18 - 50 Years)
Product Information
📋 Directions for Use
Directions For Use: Adults take 1 - 4 tablets daily or as directed by your physician.
🧪 Formulation Notes
S-adenosyl-Methionine Disulfate Tosylate
Additional Information
SAMe is a naturally derived product which helps support positive mood balance. It has been shown to support glutathione production which helps support the body's antioxidant system and healthy liver function, as well as mitigate dangerous levels of homocysteine.
Product Details
DSLD Entry Date
2017-06-23
Product Type
Other Combinations
Form
Tablet or Pill
Brand
HBC Protocols
DSLD ID
74981
Data Updated
2026-04-11
Research Evidence
14
Research Sources
50
Avg Quality Score
8
Rct
4
Meta Analysis
2
Clinical Trial
B
The Effect of Fenugreek in Type 2 Diabetes and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
B
A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes
C
The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial
C
Effect of saffron and fenugreek on lowering blood glucose: A systematic review with meta-analysis
C
Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis
C
Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials
C
Investigating the Effectiveness of Fenugreek on the Quantity of Breast Milk and the Level of Prolactin in Mothers of Preterm Newborns: A Randomized Controlled Clinical Trial
C
Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus
C
Impact of Fenugreek Supplementation on Obesity and Hyperglycemia Among Diabetic Adults in Saudi Arabia
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