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SAMe 200 mg S-Adenosyl-Methionine

product on market Tablet or Pill Life Extension Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 100% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

AI-generated · Qwen 3.6 · grounded in 1 source · methodology

S-Adenosyl Methionine (SAMe) is used to support mood and joint health. There is moderate research evidence suggesting its efficacy in managing depressive symptoms and osteoarthritis. The ingredient is generally well-tolerated, though its overall evidence coverage in this specific profile is limited.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for SAMe 200 mg S-Adenosyl-Methionine
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Enteric Coated Vegetarian Tablet(s)
Serving Size
30
Servings
Non-Nutrient/Non-Botanical
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

Market median: 200.0mg (52 products) 12 studies (A:0, B:6)

Other Ingredients

Cellulose Mannitol Methacrylic Acid Copolymer Citric Acid Stearic Acid Silica Calcium Carbonate Hypromellose Glyceryl Triacetate Sodium Starch Glycolate Croscarmellose Sodium yellow Ochre
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take one (1) tablet one to three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner. Take with co-factors vitamins B12, B6, and folic acid.

Warnings & Precautions

Caution: SAMe should not be taken by those diagnosed with bipolar disorder.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if foil is damaged.

Consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Formulation Notes

SAMe has multiple mechanisms of action that are used throughout the body

Brain and mood SAMe boosts brain cell methylation and facilitates youthful DNA enzymatic actions. These enzymatic actions are required for the healthy conversion of neurotransmitters such as norepinephrine, dopamine, and serotonin and may account for SAMe's mood-elevating properties. SAMe also helps maintain acetylcholine levels which are necessary for cognitive function. Liver and Detox In order to perform its detoxification role, the liver continually performs large numbers of complex enzymatic reactions. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of glutathione, a critical antioxidant. Joint SAMe can support healthy joint mobility and function without side effects.

Gluten free Non GMO LE Certified

Supports joints and emotional well-being

Additional Information

Non GMO LE Certified

Store in a cool dry place.

Metadata

Product Details

UPC / SKU7 37870 21753 4
DSLD Entry Date2025-06-25
Product TypeNon-Nutrient/Non-Botanical
FormTablet or Pill
DSLD ID328653
Data Updated2026-04-11
Research

Research Evidence

14
Research Sources
50
Avg Quality
8
Rct
4
Meta Analysis
2
Clinical Trial
B The Effect of Fenugreek in Type 2 Diabetes and Prediabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis International journal of molecular sciences 2023 PubMed DOI
B A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes
Rct African health sciences 2019 PubMed DOI
C The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial
Rct Complementary therapies in medicine 2020 PubMed DOI
C Effect of saffron and fenugreek on lowering blood glucose: A systematic review with meta-analysis
Meta Analysis Phytotherapy research : PTR 2023 PubMed DOI
C Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis
Meta Analysis Journal of ethnopharmacology 2016 PubMed DOI
C Effect of fenugreek extract supplement on testosterone levels in male: A meta-analysis of clinical trials
Meta Analysis Phytotherapy research : PTR 2020 PubMed DOI
C Investigating the Effectiveness of Fenugreek on the Quantity of Breast Milk and the Level of Prolactin in Mothers of Preterm Newborns: A Randomized Controlled Clinical Trial
Rct Current drug research reviews 2025 PubMed DOI
C Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus
Rct Chinese journal of integrative medicine 2008 PubMed
C Impact of Fenugreek Supplementation on Obesity and Hyperglycemia Among Diabetic Adults in Saudi Arabia
Clinical Trial ClinicalTrials.gov 2025
C Fenugreek bread: a treatment for diabetes mellitus
Rct Journal of medicinal food 2009 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.