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Appetrex Control

product on market Other (e.g. tea bag) GNC Total Lean Safety: 90/100
90/100

This product looks safe

  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 58% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains B vitamins and chromium, which are moderately supported by research for their roles in energy metabolism and blood glucose regulation. Evidence for these ingredients in weight management is generally limited. The profile maintains a high safety score with no significant concerns noted.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Contains proprietary blend — exact ingredient amounts not disclosed

Label

Product Label

Label for Appetrex Control
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Beige Tablet(s)
Serving Size
Other Combinations
Product Type
58%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

1.5 mg (100% DV)
1.2× RDA — within safe limits 76 studies (A:0, B:33)
1.7 mg (100% DV)
1.3× RDA — within safe limits 13 studies (A:0, B:1)
20 mg (100% DV)
1.4× RDA — within safe limits 196 studies (A:5, B:63)
2 mg (100% DV)
1.5× RDA — within safe limits 114 studies (A:3, B:35)
120 mcg (100% DV)
3.4× RDA — above typical dose 199 studies (A:1, B:55)
Proprietary Herbal Blend
522.5 mg
Yerba Mate extract
500 mg
Grape skin extract
210 mg
Chrysin
200 mg
Market median: 250.0mg (337 products) 127 studies (A:1, B:41)
Market median: 100.0mg (284 products) 10 studies (A:0, B:4)
Dill Weed extract
5 mg

Other Ingredients

Dicalcium Phosphate Cellulose Polyethylene Glycol Vegetable Acetoglycerides Titanium Dioxide Caramel color Ethyl Vanillin
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: As a dietary supplement, take the contents of one pak daily.

Warnings & Precautions

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

KEEP OUT OF REACH OF CHILDREN.

Formulation Notes

This scientific formula features energizing herbs like yerba mate and black tea, with EGCG which helps to support your metabolism.

GNC QUALITY COMMITMENT For more than 77 years, GNC has been the leader in the development of superior nutritional supplements. Our products are produced using only fresh, high-quality ingredients and are manufactured under the strictest quality controls. GNC GUARANTEE If you are not 100% completely satisfied, return the unused portion of the product with your receipt to a GNC store withing 30 days. Our trained sales staff will either refund your purchase price or, if you prefer, assist you in finding a replacement product to help your LIVE WELL.

Additional Information

These premium ingredients help by boosting energy and supporting metabolism.

Four separate components work together to boost your metabolism, ignite your energy, help regulate water balance and promote positive mood support.

In a randomized, double-blind, placebo-controlled study of 112 healthy volunteers, subjects taking the GNC vitamin and mineral blend in this product for six weeks experienced statistically significant improvements in markers of B vitamin and antioxidant status, as well as improvements in SF-36 Vitality and Mental Health scores compared to those taking a placebo.

{Chart} Total Calories Consumed Appetrex Control(TM) Reduces Calories Consumed Appetrex Control(TM) 550 Placebo 616

~Boosts energy, metabolism and reduces calorie intake by 10% ~Clinically studied multivitamin to fuel your active lifestyle ~Exclusive herbal blend designed to regulate water balance ~Enhanced formula includes stress defense nutrients and promotes positive mood support

CLINICALLY RESEARCHED

CODE 519811 COG

Store in a cool, dry place.

Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

{Tablet} ACTUAL SIZE

Metadata

Product Details

DSLD Entry Date2014-08-26
Product TypeOther Combinations
FormOther (e.g. tea bag)
BrandGNC Total Lean
DSLD ID36330
Data Updated2026-04-11
Research

Research Evidence

100
Research Sources
56
Avg Quality
48
Systematic Review
30
Meta Analysis
13
Rct
6
Clinical Trial
1
Cochrane Review
1
Regulatory Source
B Thiamine for prevention and treatment of Wernicke-Korsakoff Syndrome in people who abuse alcohol
Systematic Review The Cochrane database of systematic reviews 2013 PubMed DOI
B Efficacy of B-vitamins and vitamin D therapy in improving depressive and anxiety disorders: a systematic review of randomized controlled trials
Systematic Review Nutritional neuroscience 2023 PubMed DOI
B Effect of thiamine supplementation on glycaemic outcomes in adults with type 2 diabetes: a systematic review and meta-analysis
Meta Analysis BMJ open 2022 PubMed DOI
B Effect of intravenous thiamine administration on critically ill patients: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
B Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis
Systematic Review Intensive care medicine 2022 PubMed DOI
B Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis
Meta Analysis Pain medicine (Malden, Mass.) 2020 PubMed DOI
B Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of Randomized Controlled Trials With Trial Sequential Analysis
Meta Analysis Critical care medicine 2021 PubMed DOI
B The effects of thiamine supplementation on patients with heart failure: A systematic review and meta-analysis of randomized controlled trials
Meta Analysis Complementary therapies in medicine 2022 PubMed DOI
B Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis
Meta Analysis Clinical and investigative medicine. Medecine clinique et experimentale 2023 PubMed DOI
B Thiamine for Wernicke-Korsakoff Syndrome in people at risk from alcohol abuse
Systematic Review The Cochrane database of systematic reviews 2004 PubMed
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.