🟡 70/100

Review before taking

  • Niacin: 250mg is 7.1× the Tolerable Upper Intake Level (35mg)
  • Folate: 25000mg is 25000.0× the Tolerable Upper Intake Level (1.0mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 75% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 250mg is 7.1× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 25000mg is 25000.0× the Tolerable Upper Intake Level (1.0mg)
ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

This product received a low score because it contains levels of niacin and folate that significantly exceed recommended upper limits and uses a proprietary blend that does not disclose exact ingredient amounts.

Label Data

1 Capsule(s) Serving Size
60 Servings
Botanical with Nutrients Product Type
75% Evidence Coverage

Supplement Facts — Evidence Check

5 mg (384.6% DV)
📊 3.8× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)
RDA 1.3mg This product: 5mg
250 mg (1562.5% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 7.1× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 250mg UL 35mg
25000 mcg DFE (6250% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 25000.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 25000mg UL 1.0mg
Proprietary Blend
300 mg

Other Ingredients

Cellulose Rice Flour

Label Claims — Verification

All Other
Structure/Function
All Other (99% of products) Structure/Function (85% of products) Nutrient (48% of products) No Claim (1% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions for use: Start with one serving (1 Capsule) to access your tolerance. As your tolerance increases you may titrate up dosage see chart below. 1-Capsule= Minimum Flushing 2-Capsules=Medium Flushing 3-Capsules=Full Flush

⚠️ Warnings & Precautions

Warning: Keep out of the reach of children.

Consult with your health care practitioner if you are trying to get or are pregnant, nursing, taking other medications, or have other conditions.

Do not use if the safety seal is broken or missing. Always consult with your health care provider about any new dietary supplement regimen.

🧪 Formulation Notes

This product is commonly used by those who want to improve their athletic performance.

Fitness & endurance support Gluten-Free-GMP Certified

Gluten-Free-GMP Certified

Additional Information

Store in a cool, dry place.

Health Defender A Nutraceutical Company

Product Details

UPC / SKU 1 98715 72097 6
DSLD Entry Date 2025-08-22
Product Type Botanical with Nutrients
Form Capsule
DSLD ID 337344
Data Updated 2026-04-11

Research Evidence

22 Research Sources
49 Avg Quality Score
8 Rct
4 Meta Analysis
4 Clinical Trial
3 Systematic Review
1 Cochrane Review
1 Regulatory Source
B Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis
Systematic Review BMJ open 2024
B Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Meta Analysis Nutritional neuroscience 2022
B Supplementary vitamin E, selenium, cysteine and riboflavin for preventing kwashiorkor in preschool children in developing countries
Systematic Review The Cochrane database of systematic reviews 2010
B Riboflavin supplements for blood pressure lowering in adults.
Cochrane Review The Cochrane database of systematic reviews
B Associations of dietary vitamin B1, vitamin B2, vitamin B6, and vitamin B12 with the risk of depression: a systematic review and meta-analysis
Meta Analysis Nutrition reviews 2022
C Prophylaxis of migraine headaches with riboflavin: A systematic review
Systematic Review Journal of clinical pharmacy and therapeutics 2017
C Medium-dose riboflavin as a prophylactic agent in children with migraine: a preliminary placebo-controlled, randomised, double-blind, cross-over trial
Rct Cephalalgia : an international journal of headache 2010
C The efficacy of 2 different phakic intraocular lens implant in keratoconus as an isolated procedure or combined with collagen crosslinking and intra-stromal corneal ring segments: a systematic review and meta-analysis
Meta Analysis International ophthalmology 2023
C Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis
Meta Analysis The ocular surface 2014
C Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial
Rct The journal of headache and pain 2015
View all evidence for Riboflavin →

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