🟢 80/100

This product is generally safe

  • Niacin: 66mg is 1.9× the Tolerable Upper Intake Level (35mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 25% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 66mg is 1.9× the Tolerable Upper Intake Level (35mg)
ℹ️ Contains proprietary blend — exact ingredient amounts not disclosed

Label Data

3 Vegetarian Capsule(s) Serving Size
30 Servings
Botanical with Nutrients Product Type
25% Evidence Coverage

Supplement Facts — Evidence Check

66 mg NE (413% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 1.9× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 66mg UL 35mg
1000 mg
📊 Market median: 500.0mg (70 products)
Median 500.0mg This product: 1000mg
250 mg
📊 Market median: 500.0mg (159 products)
Median 500.0mg This product: 250mg
📊 Market median: 500.0mg (70 products)
Median 500.0mg This product: 285mg

Other Ingredients

Cellulose Microcrystalline Cellulose Maltodextrin Starch Carboxymethyl Cellulose Stearate Silica

Label Claims — Verification

All Other
Structure/Function
All Other (100% of products) Structure/Function (90% of products) Nutrient (61% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: Take three (3) capsules all at once before bedtime, or one capsule on an empty stomach before each meal, or as recommended by a healthcare practitioner. Best if taken separately from protein or amino acids.

⚠️ Warnings & Precautions

Read the entire label and follow the directions carefully.

Caution: Consult your healthcare provider before using this product if you are taking medication for mood concerns, such as MAOIs or SSRIs.

Use caution before driving or operating heavy machinery.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is damaged.

Consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

🧪 Formulation Notes

Gluten free Non GMO LE Certified

Sleep enhancement and stress reduction

Additional Information

Scan for product info

Store tightly closed in a cool, dry place.

Non GMO LE Certified

Product Details

UPC / SKU 7 37870 17219 2
DSLD Entry Date 2025-04-24
Product Type Botanical with Nutrients
Form Capsule
DSLD ID 328618
Data Updated 2026-04-11

Research Evidence

29 Research Sources
48 Avg Quality Score
19 Rct
5 Meta Analysis
3 Systematic Review
2 Clinical Trial
B Prebiotic and probiotic supplementation and the tryptophan-kynurenine pathway: A systematic review and meta analysis
Meta Analysis Neuroscience and biobehavioral reviews 2021
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002
B The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression
Meta Analysis Nutrition reviews 2022
B No effects of acute tryptophan depletion on anxiety or mood in weight-recovered female patients with anorexia nervosa
Rct European archives of psychiatry and clinical neuroscience 2023
C The association between tryptophan levels and postpartum mood disorders: a systematic review and meta-analysis
Meta Analysis BMC psychiatry 2022
C A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning
Systematic Review Journal of dietary supplements 2021
C Comparison between Acupuncture and Nutraceutical Treatment with Migratens® in Patients with Fibromyalgia Syndrome: A Prospective Randomized Clinical Trial.
Rct Nutrients
C Intake of Lactiplantibacillus plantarum HEAL9 Improves Cognition in Moderately Stressed Subjects: A Randomized Controlled Study.
Rct Nutrients
C Are tryptophan and 5-hydroxytryptophan effective treatments for depression? A meta-analysis
Meta Analysis The Australian and New Zealand journal of psychiatry 2002
View all evidence for Tryptophan →

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