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Optimized Tryptophan Plus

product on market Capsule Life Extension Safety: 80/100
80/100

This product is generally safe

  • Niacin: 66mg is 1.9× the Tolerable Upper Intake Level (35mg)
  • Contains proprietary blend — exact ingredient amounts not disclosed
  • 25% of ingredients have research evidence
C Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

L-tryptophan and niacin are supported by moderate evidence for roles in mood regulation and metabolic function, while L-lysine is used for cellular support. Overall evidence coverage for this specific formulation is limited. The profile maintains a high safety score, indicating a generally low risk of adverse effects.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 66mg is 1.9× the Tolerable Upper Intake Level (35mg)

Contains proprietary blend — exact ingredient amounts not disclosed

Label

Product Label

Label for Optimized Tryptophan Plus
Open Full PDF View on NIH DSLD →
Details

Label Data

3 Vegetarian Capsule(s)
Serving Size
30
Servings
Botanical with Nutrients
Product Type
25%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

66 mg NE (413% DV)
Exceeds UL by 1.9× (UL: 35 mg) 196 studies (A:5, B:63)
1000 mg
Market median: 500.0mg (70 products)
250 mg
Market median: 500.0mg (159 products)
Market median: 500.0mg (70 products)

Other Ingredients

Cellulose Microcrystalline Cellulose Maltodextrin Starch Carboxymethyl Cellulose Stearate Silica
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take three (3) capsules all at once before bedtime, or one capsule on an empty stomach before each meal, or as recommended by a healthcare practitioner. Best if taken separately from protein or amino acids.

Warnings & Precautions

Read the entire label and follow the directions carefully.

Caution: Consult your healthcare provider before using this product if you are taking medication for mood concerns, such as MAOIs or SSRIs.

Use caution before driving or operating heavy machinery.

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not purchase if outer seal is damaged.

Consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Formulation Notes

Gluten free Non GMO LE Certified

Sleep enhancement and stress reduction

Additional Information

Scan for product info

Store tightly closed in a cool, dry place.

Non GMO LE Certified

Metadata

Product Details

UPC / SKU7 37870 17219 2
DSLD Entry Date2025-04-24
Product TypeBotanical with Nutrients
FormCapsule
BrandLife Extension
DSLD ID328618
Data Updated2026-04-11
Research

Research Evidence

29
Research Sources
48
Avg Quality
19
Rct
5
Meta Analysis
3
Systematic Review
2
Clinical Trial
B Prebiotic and probiotic supplementation and the tryptophan-kynurenine pathway: A systematic review and meta analysis
Meta Analysis Neuroscience and biobehavioral reviews 2021 PubMed DOI
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2001 PubMed
B Tryptophan and 5-hydroxytryptophan for depression
Systematic Review The Cochrane database of systematic reviews 2002 PubMed
B The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression
Meta Analysis Nutrition reviews 2022 PubMed DOI
B No effects of acute tryptophan depletion on anxiety or mood in weight-recovered female patients with anorexia nervosa
Rct European archives of psychiatry and clinical neuroscience 2023 PubMed DOI
C The association between tryptophan levels and postpartum mood disorders: a systematic review and meta-analysis
Meta Analysis BMC psychiatry 2022 PubMed DOI
C A systematic review of the effect of L-tryptophan supplementation on mood and emotional functioning
Systematic Review Journal of dietary supplements 2021 PubMed DOI
C Comparison between Acupuncture and Nutraceutical Treatment with Migratens® in Patients with Fibromyalgia Syndrome: A Prospective Randomized Clinical Trial.
Rct Nutrients PubMed DOI
C Intake of Lactiplantibacillus plantarum HEAL9 Improves Cognition in Moderately Stressed Subjects: A Randomized Controlled Study.
Rct Nutrients PubMed DOI
C Are tryptophan and 5-hydroxytryptophan effective treatments for depression? A meta-analysis
Meta Analysis The Australian and New Zealand journal of psychiatry 2002 PubMed
View all evidence for Tryptophan →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.