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Methyl Folate Plus

product on market Capsule Neurobiologix Safety: 74/100
74/100

Review before taking

  • Niacin: 125mg is 3.6× the Tolerable Upper Intake Level (35mg)
  • Folate: 9770mg is 9770.0× the Tolerable Upper Intake Level (1.0mg)
  • 100% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · grounded in 1 source · methodology

Riboflavin, niacin, and folate are B vitamins that support cellular energy production and neurological function. There is strong research evidence for their roles in metabolic health, though evidence coverage for this specific formulation is limited. The ingredient profile is generally considered safe for most adults.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 125mg is 3.6× the Tolerable Upper Intake Level (35mg)

Folate: 9770mg is 9770.0× the Tolerable Upper Intake Level (1.0mg)

✨ AI-generated · Qwen 3.6 · grounded in 2 sources · methodology

This product received a low safety score because it contains levels of Niacin and Folate that significantly exceed the recommended daily upper limits.

Label

Product Label

Label for Methyl Folate Plus
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Vegetable Capsule(s)
Serving Size
90
Servings
Vitamin
Product Type
100%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

30 mg (2308% DV)
23.1× RDA — above typical dose 13 studies (A:0, B:1)
125 mg (781% DV)
Exceeds UL by 3.6× (UL: 35 mg) 196 studies (A:5, B:63)
9770 mcg DFE (2443% DV)
Exceeds UL by 9770.0× (UL: 1.0 mg) 226 studies (A:10, B:105)

Other Ingredients

Hypromellose Rice Flour Ascorbyl Palmitate Silicon Dioxide
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Suggested use: Take 1 capsule twice daily or as directed by your healthcare practitioner.

For use as a dietary supplement.

Warnings & Precautions

Do not use if seal is broken.

Caution: Keep out of reach of children.

Professional use only

Formulation Notes

Methyl Folate Plus overcomes deficiencies in the cellular delivery of methyl folate by providing the necessary nutrient cofactors.

This formula supports those who have methylation deficiencies due to genetic weaknesses. This formula is commonly used for those who need additional nervous and immune system support. This product meets or exceeds cGMP quality standards.

Free of: Wheat, gluten, corn protein, soy, dairy products, artificial colors or preservatives.

Professional grade

Methyl Folate Plus with activating co-factor

Gluten free Soy free Dairy free

Additional Information

Storage: Keep tightly closed in a cool, dry place.

GMP Good Manufacturing Practice Consistent Quality

Exclusive formula

Metadata

Product Details

UPC / SKU8 54998 00608 3
DSLD Entry Date2025-02-23
Product TypeVitamin
FormCapsule
BrandNeurobiologix
DSLD ID327686
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.