Methyl Folate Plus by Neurobiologix — Ingredients, Evidence & Safety

🟡 74/100

Review before taking

Niacin: 125mg is 3.6× the Tolerable Upper Intake Level (35mg)
Folate: 9770mg is 9770.0× the Tolerable Upper Intake Level (1.0mg)
100% of ingredients have research evidence

D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 125mg is 3.6× the Tolerable Upper Intake Level (35mg)

⚠️ Folate: 9770mg is 9770.0× the Tolerable Upper Intake Level (1.0mg)

This product received a low safety score because the amounts of Niacin and Folate it contains significantly exceed the recommended maximum daily intake limits.

Label Data

1 Vegetable Capsule(s) Serving Size

90 Servings

Vitamin Product Type

100% Evidence Coverage

Supplement Facts — Evidence Check

Riboflavin

30 mg (2308% DV)

📊 23.1× RDA — above typical dose 📚 12 studies (Tier A: 0, B: 1)

RDA 1.3mg This product: 30mg

Niacin

125 mg (781% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 3.6× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)

RDA 14mg This product: 125mg UL 35mg

Folate

9770 mcg DFE (2443% DV)

⚠️ Exceeds Tolerable Upper Intake Level by 9770.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)

RDA 0.4mg This product: 9770mg UL 1.0mg

Other Ingredients

Hypromellose Rice Flour Ascorbyl Palmitate Silicon Dioxide

Label Claims — Verification

❓ Nutrient

❓ All Other

❓ Structure/Function

All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested use: Take 1 capsule twice daily or as directed by your healthcare practitioner.

For use as a dietary supplement.

⚠️ Warnings & Precautions

Do not use if seal is broken.

Caution: Keep out of reach of children.

Professional use only

🧪 Formulation Notes

Methyl Folate Plus overcomes deficiencies in the cellular delivery of methyl folate by providing the necessary nutrient cofactors.

This formula supports those who have methylation deficiencies due to genetic weaknesses. This formula is commonly used for those who need additional nervous and immune system support. This product meets or exceeds cGMP quality standards.

Free of: Wheat, gluten, corn protein, soy, dairy products, artificial colors or preservatives.

Professional grade

Methyl Folate Plus with activating co-factor

Gluten free Soy free Dairy free

Additional Information

Storage: Keep tightly closed in a cool, dry place.

GMP Good Manufacturing Practice Consistent Quality

Exclusive formula

Product Details

UPC / SKU 8 54998 00608 3

DSLD Entry Date 2025-02-23

Product Type Vitamin

Form Capsule

Brand Neurobiologix

DSLD ID 327686

Data Updated 2026-04-11

Research Evidence

363 Research Sources

57 Avg Quality Score

187 Meta Analysis

56 Systematic Review

54 Rct

29 Guideline

26 Clinical Trial

6 Cochrane Review

2 Regulatory Source

1 Other

1 Openfda Safety

A Homocysteine-lowering interventions for preventing cardiovascular events

Meta Analysis The Cochrane database of systematic reviews 2017

PubMed DOI

A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes

Meta Analysis The Cochrane database of systematic reviews 2015

PubMed DOI

A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies

Meta Analysis Digestive diseases and sciences 2021

PubMed DOI

A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis

Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021

PubMed DOI

A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Meta Analysis Nutrients 2024

PubMed DOI

A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis

Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025

PubMed DOI

A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies

Meta Analysis Critical reviews in food science and nutrition 2019

PubMed DOI

A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials

Meta Analysis Critical reviews in food science and nutrition 2022

PubMed DOI

A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants

Meta Analysis Critical reviews in food science and nutrition 2023

PubMed DOI

A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care

Meta Analysis The Cochrane database of systematic reviews 2025

PubMed DOI

View all evidence for Folate →