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Methyl Folate Optimizer

product on market Capsule NuMedica Safety: 87/100
87/100

This product is generally safe

  • Niacin: 150mg is 4.3× the Tolerable Upper Intake Level (35mg)
  • Folate: 10200mg is 10200.0× the Tolerable Upper Intake Level (1.0mg)
  • 67% of ingredients have research evidence
D Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains B vitamins, including folate and B12, which are supported by strong evidence for supporting methylation and neurological function. Niacin and B6 further contribute to energy metabolism and cognitive health. The inclusion of AstraGin aims to enhance nutrient absorption, though evidence for this specific additive is more limited.

AI-generated summary based on research evidence. Not medical advice.

Alerts

Safety Alerts

Niacin: 150mg is 4.3× the Tolerable Upper Intake Level (35mg)

Folate: 10200mg is 10200.0× the Tolerable Upper Intake Level (1.0mg)

Label

Product Label

Label for Methyl Folate Optimizer
Open Full PDF View on NIH DSLD →
Details

Label Data

2 Capsule(s)
Serving Size
30
Servings
Botanical with Nutrients
Product Type
67%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

150 mg NE (938% DV)
Exceeds UL by 4.3× (UL: 35 mg) 196 studies (A:5, B:63)
25 mg (1471% DV)
19.2× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
10200 mcg DFE (2550% DV)
Exceeds UL by 10200.0× (UL: 1.0 mg) 226 studies (A:10, B:105)
1000 mcg (41667% DV)
416.7× RDA — above typical dose 139 studies (A:1, B:44)
AstraGin
12.5 mg
BioPerine
2 mg

Other Ingredients

Microcrystalline Cellulose Hydroxypropyl Methylcellulose Bamboo Silica
Claims

Label Claims — Verification

Unverified Nutrient
Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Directions: Take two capsules once per day with a meal or as directed by your healthcare practitioner.

Warnings & Precautions

Caution: Keep out of reach of children.

Formulation Notes

Methyl Folate Optimizer is a comprehensive formula designed to support optimal methylation and homocysteine levels. Vitamin B-12 is also provided in its active form, methylcobalamin, to further support methylation and healthy homocysteine levels. NuMedica has included its Enhanced Absorption Technology - a proprietary blend of AstraGin and BioPerine.

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy. Sourced from non-GMO ingredients.

Vegetarian

Gluten-Free

AstraGin BioPerine Activated B-Vitamins

Methyl Folate Optimizer with AstraGin and BioPerine for optimal Absorption

Supports Optimal Methylation

Additional Information

Storage: Keep tightly closed in a cool, dry place.

cGMP Third-Party Certified Facility

Professional Quality Formulas

Metadata

Product Details

UPC / SKU8 12527 01011 6
DSLD Entry Date2025-01-23
Product TypeBotanical with Nutrients
FormCapsule
BrandNuMedica
DSLD ID323579
Data Updated2026-04-11
Research

Research Evidence

363
Research Sources
57
Avg Quality
187
Meta Analysis
56
Systematic Review
54
Rct
29
Guideline
26
Clinical Trial
6
Cochrane Review
2
Regulatory Source
1
Other
1
Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017 PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021 PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021 PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024 PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022 PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023 PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025 PubMed DOI
View all evidence for Folate →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.