Methyl Folate Optimizer

product on market Capsule NuMedica 🟢 Safety: 87/100
Brand: NuMedica
🟢 87/100

This product is generally safe

  • Niacin: 150mg is 4.3× the Tolerable Upper Intake Level (35mg)
  • Folate: 10200mg is 10200.0× the Tolerable Upper Intake Level (1.0mg)
  • 67% of ingredients have research evidence
D Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Niacin: 150mg is 4.3× the Tolerable Upper Intake Level (35mg)
⚠️ Folate: 10200mg is 10200.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

2 Capsule(s) Serving Size
30 Servings
Botanical with Nutrients Product Type
67% Evidence Coverage

Supplement Facts — Evidence Check

150 mg NE (938% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 4.3× (UL: 35 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 150mg UL 35mg
25 mg (1471% DV)
📊 19.2× RDA — above typical dose (UL: 100 mg) 📚 113 studies (Tier A: 3, B: 35)
RDA 1.3mg This product: 25mg UL 100mg
10200 mcg DFE (2550% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 10200.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 10200mg UL 1.0mg
1000 mcg (41667% DV)
📊 416.7× RDA — above typical dose 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 1.0mg
AstraGin
12.5 mg
BioPerine
2 mg

Other Ingredients

Microcrystalline Cellulose Hydroxypropyl Methylcellulose Bamboo Silica

Label Claims — Verification

❓ Nutrient
❓ All Other
❓ Structure/Function
All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free

Product Information

📋 Directions for Use

Directions: Take two capsules once per day with a meal or as directed by your healthcare practitioner.

⚠️ Warnings & Precautions

Caution: Keep out of reach of children.

🧪 Formulation Notes

Methyl Folate Optimizer is a comprehensive formula designed to support optimal methylation and homocysteine levels. Vitamin B-12 is also provided in its active form, methylcobalamin, to further support methylation and healthy homocysteine levels. NuMedica has included its Enhanced Absorption Technology - a proprietary blend of AstraGin and BioPerine.

Does not contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy. Sourced from non-GMO ingredients.

Vegetarian

Gluten-Free

AstraGin BioPerine Activated B-Vitamins

Methyl Folate Optimizer with AstraGin and BioPerine for optimal Absorption

Supports Optimal Methylation

Additional Information

Storage: Keep tightly closed in a cool, dry place.

cGMP Third-Party Certified Facility

Professional Quality Formulas

Product Details

UPC / SKU 8 12527 01011 6
DSLD Entry Date 2025-01-23
Product Type Botanical with Nutrients
Form Capsule
Brand NuMedica
DSLD ID 323579
Data Updated 2026-04-11

Research Evidence

363 Research Sources
57 Avg Quality Score
187 Meta Analysis
56 Systematic Review
54 Rct
29 Guideline
26 Clinical Trial
6 Cochrane Review
2 Regulatory Source
1 Other
1 Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
PubMed DOI
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
PubMed DOI
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021
PubMed DOI
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021
PubMed DOI
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024
PubMed DOI
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
PubMed DOI
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022
PubMed DOI
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023
PubMed DOI
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025
PubMed DOI
View all evidence for Folate →

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