Circulation & Vein Formula

product on market Capsule SigmaCeutical 🟢 Safety: 100/100
Brand: SigmaCeutical
🟢 100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 38% of ingredients have research evidence
A Label Compliance Grade

Product Label

Label for Circulation & Vein Formula
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Label Data

1 Capsule(s) Serving Size
90 Servings
Other Combinations Product Type
38% Evidence Coverage

Supplement Facts — Evidence Check

10 mg (50% DV)
✅ Within RDA (0.7× RDA of 14 mg) 📚 193 studies (Tier A: 5, B: 63)
RDA 14mg This product: 10mg UL 35mg
250 mg
📊 Market median: 333.0mg (166 products) 📚 9 studies (Tier A: 0, B: 2)
This product: 250mg
100 mg
📊 Market median: 250.0mg (337 products) 📚 125 studies (Tier A: 1, B: 41)
This product: 100mg
50 mg
📊 Market median: 500.0mg (143 products)
This product: 50mg
Butchers Broom root extract
25 mg
Cayenne Pepper fruit, Powder
25 mg
25 mg
📊 Market median: 285.0mg (90 products) 📚 1 studies — no high-quality reviews
This product: 25mg
Diosmin
5 mg

Other Ingredients

Gelatin Magnesium Stearate Rice Flour

Label Claims — Verification

❓ All Other
❓ Structure/Function
All Other (97% of products) Structure/Function (86% of products) Nutrient (36% of products)

Target Groups

Adult (18 - 50 Years) Women (not pregnant or lactating)

Product Information

📋 Directions for Use

Suggested use: 1 capsule taken 1 to 3 times daily preferably with meals or as directed by a healthcare professional.

⚠️ Warnings & Precautions

Caution: Do not exceed recommended dose. If you are diabetic, or have a known medical condition, consult your physician prior to taking this or any dietary supplement. Notice: Most people should not experience "Niacin skin flush" when using this product. However a few sensitive individuals may experience some flushing. Do not take on an empty stomach.

This product is not intended for pregnant or nursing mothers of children under the age of 18.

This product is not intended for pregnant or nursing mothers of children under the age of 18.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

🧪 Formulation Notes

World class nutritional supplement formulations

Circulation & Vein Formula with Cayenne & Ginger

Additional Information

Sourced from a GMP Certified Facility Good Manufacturing Practice Quality Assured Formulated in USA

Please go to www.sigmaceutical.com for special discounts & offers! The sum of all health

Store in a cool, dry place.

Product Details

UPC / SKU X001QV9IXD
DSLD Entry Date 2025-01-23
Product Type Other Combinations
Form Capsule
Brand SigmaCeutical
DSLD ID 321751
Data Updated 2026-04-11

Research Evidence

241 Research Sources
55 Avg Quality Score
113 Meta Analysis
75 Systematic Review
32 Rct
11 Clinical Trial
3 Other
3 Regulatory Source
1 Cochrane Review
1 Narrative Review
1 Openfda Safety
A Niacin for primary and secondary prevention of cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
PubMed DOI Cochrane
A Use of high potency statins and rates of admission for acute kidney injury: multicenter, retrospective observational analysis of administrative databases
Meta Analysis BMJ (Clinical research ed.) 2013
PubMed DOI
A Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients
Meta Analysis BMJ (Clinical research ed.) 2014
PubMed DOI
A A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Meta Analysis Nature medicine 2024
PubMed DOI
A Meta-analysis and imputation refines the association of 15q25 with smoking quantity
Meta Analysis Nature genetics 2010
PubMed DOI
A Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Meta Analysis Nature genetics 2010
PubMed DOI
A Antidepressants for smoking cessation
Meta Analysis The Cochrane database of systematic reviews 2014
PubMed DOI
A Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne
Meta Analysis The Cochrane database of systematic reviews 2020
PubMed DOI Cochrane
B Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis
Meta Analysis JAMA network open 2019
PubMed DOI
B Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis
Meta Analysis JAMA 2016
PubMed DOI
View all evidence for Niacin →

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