🟢 95/100

This product looks safe

  • Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)
  • 50% of ingredients have research evidence
C Label Compliance Grade

Product Label

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Safety Alerts

⚠️ Folate: 400mg is 400.0× the Tolerable Upper Intake Level (1.0mg)

Label Data

1 Capsule(s) Serving Size
30 Servings
Other Combinations Product Type
50% Evidence Coverage

Supplement Facts — Evidence Check

400 mcg DFE (100% DV)
⚠️ Exceeds Tolerable Upper Intake Level by 400.0× (UL: 1.0 mg) 📚 225 studies (Tier A: 10, B: 105)
RDA 0.4mg This product: 400mg UL 1.0mg
6 mcg (250% DV)
✅ 2.5× RDA — within safe limits 📚 138 studies (Tier A: 1, B: 44)
RDA 0.0024mg This product: 0.006mg
Calcium
75 mg (6% DV)
200 mcg (364% DV)
📊 3.6× RDA — above typical dose (UL: 0.4 mg) 📚 172 studies (Tier A: 0, B: 67)
RDA 0.055mg This product: 0.2mg UL 0.4mg
4 mg
📊 Market median: 10.0mg (35 products) 📚 5 studies (Tier A: 0, B: 2)
This product: 4mg
Immune System Support Blend
912 mg
DNA Methylation Complex
463 mg
RM-10 Ultra Organic Mushroom Blend
273 mg

Other Ingredients

Cellulose Brown Rice

Label Claims — Verification

Nutrient
All Other
Structure/Function
All Other (99% of products) Structure/Function (77% of products) Nutrient (60% of products) Approved Health (5% of products)

Target Groups

Vegetarian Adult (18 - 50 Years) Gluten Free Dairy Free

Product Information

📋 Directions for Use

Suggested use: Adults take 1 capsule 3 times daily. Best taken on an empty stomach.

⚠️ Warnings & Precautions

Not intended for children. Keep out of reach of children. Caution: As with any dietary supplement, consult your healthcare practitioner before using this product, especially if you are pregnant, nursing, giving product to children, anticipate surgery, take medication on a regular basis or are otherwise under medical supervision.

Caution: As with any dietary supplement, consult your healthcare practitioner before using this product, especially if you are pregnant, nursing, giving product to children, anticipate surgery, take medication on a regular basis or are otherwise under medical supervision.

Do not use if safety seal is broken or missing.

Manufactured in a facility that also processes soy, dairy, peanut, tree nuts and shellfish.

🧪 Formulation Notes

BioProtect Packaging system Ultimate immune system support Broad spectrum support for immune cell function

The methylation connection DNA methylation is a normal biochemical process that occurs in the body, important in regulating cell identity and growth.

RM-10 Ultra contains a full range of nutrients that support healthy DNA methylation needed for optimum health Betaine, Vitamin B12 and Folate play a critical role in normal methylation by supporting the body's conversion of homocysteine into methionine, a key donor to cellular methylation.

Certified by the nonprofit B Lab to meet rigorous standards of social and environmental performance, accountability and transparency.

Vegetarian

Gluten free Dairy free

Broad spectrum support RM-10 Ultra is the ultimate immune system support formula, containing organically grown mushrooms and other specially selected ingredients that provide broad spectrum immune system support via multiple pathways: Immune cell function support Immune cell metabolism support Methylation support Antioxidant support

Made without dairy or soy ingredients, peanuts, tree nuts or shellfish. No artificial colors or preservatives.

Made in U.S.A. from foods grown in the U.S.A. and other countries.

Additional Information

Certified B Corporation Certified Renewable Energy Green-e.org We Buy 100% Certified Renewable Energy

Printed with vegetable based inks on 100% recycled material

Store in a cool, dry place.

Package size is determined by labeling information not the number of servings in this container. The serving size and contents are clearly marked.

Product Details

UPC / SKU 6 58010 11255 0
DSLD Entry Date 2025-01-23
Product Type Other Combinations
Form Capsule
DSLD ID 321368
Data Updated 2026-04-11

Research Evidence

363 Research Sources
57 Avg Quality Score
187 Meta Analysis
56 Systematic Review
54 Rct
29 Guideline
26 Clinical Trial
6 Cochrane Review
2 Regulatory Source
1 Other
1 Openfda Safety
A Homocysteine-lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2017
A Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015
A Folate Intake and Risk of Pancreatic Cancer: A Systematic Review and Updated Meta-Analysis of Epidemiological Studies
Meta Analysis Digestive diseases and sciences 2021
A The Association Between the Risk of Hypertensive Disorders of Pregnancy and Folic Acid: A Systematic Review and Meta-Analysis
Meta Analysis Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 2021
A A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Meta Analysis Nutrients 2024
A Associations between serum Homocysteine, vitamin B9, and vitamin B12 levels and the formation of intracranial Aneurysms: A systematic review and meta-analysis
Meta Analysis Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2025
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019
A Beneficial effects of folic acid supplementation on lipid markers in adults: A GRADE-assessed systematic review and dose-response meta-analysis of data from 21,787 participants in 34 randomized controlled trials
Meta Analysis Critical reviews in food science and nutrition 2022
A Folic acid supplementation and blood pressure: a GRADE-assessed systematic review and dose-response meta-analysis of 41,633 participants
Meta Analysis Critical reviews in food science and nutrition 2023
A Digital tracking, provider decision support systems, and targeted client communication via mobile devices to improve primary health care
Meta Analysis The Cochrane database of systematic reviews 2025
View all evidence for Folate →

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