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R.E.M.

product on market Capsule Priority One Nutritional Supplements Safety: 100/100
100/100

This product looks safe

  • No ingredients exceed tolerable upper intake levels
  • 47% of ingredients have research evidence
A Label Compliance Grade

What the Evidence Says

✨ AI-generated · Qwen 3.6 · methodology

This formula contains B vitamins and minerals like magnesium and calcium, which are supported by strong evidence for their roles in energy metabolism and neurological function. While these ingredients are well-researched, the overall evidence coverage for this specific combination is limited. The profile maintains a high safety score.

AI-generated summary based on research evidence. Not medical advice.

Label

Product Label

Label for R.E.M.
Open Full PDF View on NIH DSLD →
Details

Label Data

1 Capsule(s)
Serving Size
30
Servings
Other Combinations
Product Type
47%
Evidence Coverage
Ingredients

Supplement Facts — Evidence Check

4 mg (235% DV)
3.1× RDA — above typical dose (UL: 100 mg) 114 studies (A:3, B:35)
100 mcg (4167% DV)
41.7× RDA — above typical dose 139 studies (A:1, B:44)
18 mg (360% DV)
3.6× RDA — above typical dose 2 studies — no high-quality reviews
Calcium
50 mg (4% DV)
12 mg (3% DV)
Market median: 500.0mg (1 products) 316 studies (A:8, B:159)
L-Glutathione
3 mg
Hops Strobile Extract
4 mg
Lemon Balm Leaf Extract
5 mg
1 mg
Market median: 3.0mg (984 products) 240 studies (A:2, B:109)
10 mg
Market median: 550.0mg (217 products) 29 studies (A:0, B:5)
Market median: 100.0mg (116 products) 18 studies (A:0, B:3)
Market median: 60.0mg (107 products) 1 studies — no high-quality reviews
Jujube Seed Extract
10 mg
10 mg
Market median: 200.0mg (358 products) 9 studies (A:0, B:2)
Market median: 420.0mg (127 products) 4 studies (A:0, B:1)
Gamma Amino Butyric Acid
50 mg
Market median: 4002.0mg (1 products) 21 studies (A:0, B:2)
Market median: 1000.0mg (2 products)
Market median: 100.0mg (108 products)

Other Ingredients

Maltodextrin Hypromellose Water, Purified
Claims

Label Claims — Verification

Unverified All Other
Unverified Structure/Function
Info

Product Information

Directions for Use

Recommendations: Take one (1) capsules daily, or as directed by your physician.

Warnings & Precautions

Warning: Contains licorice root.

Do not take during pregnancy.

Consult your physician before using this product.

Keep out of reach of children.

For professional use only.

Contains soy (phosphatidyl serine)

Formulation Notes

Contains no preservatives. Bisphenol-A (BPA) & Phthalate Free

Vegetarian formulation

Support for healthy sleep cycles.

Not a significant source of total sugars.

Additional Information

Keep container tightly closed, store in a cool, dry place.

GMP Certified

Metadata

Product Details

UPC / SKU8 15354 02119 5
DSLD Entry Date2024-07-25
Product TypeOther Combinations
FormCapsule
BrandPriority One Nutritional Supplements
DSLD ID310779
Data Updated2026-04-11
Research

Research Evidence

153
Research Sources
55
Avg Quality
71
Systematic Review
51
Meta Analysis
19
Rct
6
Clinical Trial
2
Other
2
Regulatory Source
1
Openfda Safety
A Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials
Meta Analysis BMJ (Clinical research ed.) 2013 PubMed DOI
A Homocysteine lowering interventions for preventing cardiovascular events
Meta Analysis The Cochrane database of systematic reviews 2009 PubMed DOI
A Intake of vitamin B6, folate, and vitamin B12 and risk of coronary heart disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Meta Analysis Critical reviews in food science and nutrition 2019 PubMed DOI
A Exploring the causal associations of micronutrients on urate levels and the risk of gout: A Mendelian randomization study
Meta Analysis Clinical nutrition (Edinburgh, Scotland) 2024 PubMed DOI
A Pyridoxine (vitamin B6) supplementation during pregnancy or labour for maternal and neonatal outcomes
Meta Analysis The Cochrane database of systematic reviews 2015 PubMed DOI
B Prophylactic drug management for febrile seizures in children
Meta Analysis The Cochrane database of systematic reviews 2021 PubMed DOI
B Treatments for Hyperemesis Gravidarum and Nausea and Vomiting in Pregnancy: A Systematic Review
Systematic Review JAMA 2016 PubMed DOI
B The potential role of nutritional components in improving brain function among patients with Alzheimers disease: a meta-analysis of RCT studies
Meta Analysis Neurosciences (Riyadh, Saudi Arabia) 2020 PubMed DOI
B Pyridoxine (vitamin B6) supplementation in pregnancy
Meta Analysis The Cochrane database of systematic reviews 2006 PubMed
B Effect of ginger in the treatment of nausea and vomiting compared with vitamin B6 and placebo during pregnancy: a meta-analysis
Meta Analysis The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2022 PubMed DOI
View all evidence for Vitamin B6 →
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This product page is for informational purposes only and does not constitute medical advice. Always consult your healthcare provider before taking any supplement.